Medium-chain triglycerides dietary supplement improves cognitive abilities in canine epilepsy
| Autor: | Annette Wessmann, Anna Knebel, Rowena M. A. Packer, Ludovic Pelligand, Andrea Tipold, Benjamin-Andreas Berk, Tarja S. Jokinen, Tsz Hong Law, Holger A. Volk, Andrea Bathen-Nöthen |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Dietary supplement 03 medical and health sciences Behavioral Neuroscience Epilepsy chemistry.chemical_compound 0302 clinical medicine Animal model Cognition Dogs Internal medicine Seizure control Medicine Animals Humans Dietary supplementation 030212 general & internal medicine Prospective Studies Triglycerides 2. Zero hunger Triglyceride business.industry medicine.disease Cognitive test Neurology chemistry Dietary Supplements Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Epilepsybehavior : EB. 114 |
| ISSN: | 1525-5069 |
| Popis: | Objective Cognitive impairments (CI) have recently been identified in canine epilepsy patients. A medium-chain triglyceride (MCT) enriched diet has been demonstrated to improve cognition in aged dogs and seizure control in canine epilepsy. This study evaluates the short-term effects of MCT-oil consumption on cognitive abilities in dogs with epilepsy, a naturally occurring animal model. Methods A 6-month multicenter, prospective, randomized, double-blinded, controlled cross-over diet trial was conducted comparing dietary supplementation (DS) of MCT oil to a control oil. Allocation to dietary oil supplements, consisting of 9% total caloric intake, was block-randomized and supplemented into each dogs’ diet for 3 months followed by a respective switch of DS-oil for a further 3 months. Noninvasive cognitive tests and a validated psychometric tool were utilized to evaluate cognitive function and perturbations associated with dietary intervention. Results Twenty-nine dogs completed the trial, of which 18 completed noninvasive cognitive testing. Spatial-working memory (P = 0.008), problem-solving ability (P = 0.048), and owner-reported trainability (P = 0.041) were significantly improved during MCT-oil supplementation compared to control-DS. Significance MCT-oil DS improves cognition in dogs with epilepsy when compared to a control-DS. MCT supplementation may represent a promising option to address CI associated with epilepsy. |
| Databáze: | OpenAIRE |
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