Vitamin D and Anti-Müllerian Hormone Levels in Infertility Treatment: The Change-Point Problem
| Autor: | Anita Olejek, Katarzyna Olszak-Wąsik, Anna Bednarska-Czerwińska, And Andrzej Tukiendorf, Michał Czerwiński |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Anti-Mullerian Hormone Infertility endocrine system Pregnancy Rate medicine.medical_treatment 030209 endocrinology & metabolism vitamin D lcsh:TX341-641 Fertilization in Vitro Controlled ovarian hyperstimulation Article Cohort Studies Andrology 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Vitamin D and neurology Humans Prospective Studies segmented regression 030219 obstetrics & reproductive medicine Nutrition and Dietetics In vitro fertilisation biology business.industry Anti-Müllerian hormone medicine.disease Follicular fluid follicular fluid anti-Müllerian hormone biology.protein Female Seasons business Infertility Female lcsh:Nutrition. Foods and food supply Embryo quality Food Science Hormone |
| Zdroj: | Nutrients, Vol 11, Iss 5, p 1053 (2019) Nutrients Volume 11 Issue 5 |
| ISSN: | 2072-6643 |
| Popis: | Background: Anti-Mü llerian hormone (AMH) is considered to be one of the most significant indicators of women&rsquo s fertility. Many studies have shown that vitamin D may modify human reproductive functions however, the results are conflicting. The composition of follicular fluid (FF) creates the biochemical environment of the oocyte and affects its quality, which later determines the embryo quality. In this study, we aimed to revise with advanced statistical techniques the relationship between AMH and vitamin D in FF. Methods: The study was designed as a prospective single-center study in infertile patients with AMH &ge 0.7 ng/mL who underwent controlled ovarian hyperstimulation for in vitro fertilization. AMH and vitamin D levels in FF were measured. Next, the standard and advanced statistical (including segmented regression) techniques were applied. Results: We observed a negative linear correlation between levels of AMH in serum and FF and total vitamin D concentrations up to approximately 30 ng/ml with a statistically significant relationship in FF. Beyond that concentration, the trend was positive but statistically insignificant. Conclusions: As an existing &ldquo change-point problem&rdquo was noticed, we suggest segmentation in the relationship between vitamin D and AMH during infertility treatment. |
| Databáze: | OpenAIRE |
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