Detection of 21-deoxycortisol in blood from a patient with congenital adrenal hyperplasia
| Autor: | Donald E. Maynard, Ralph G. Wieland, Thomas R. Riley, George J. Hamwi |
|---|---|
| Rok vydání: | 1965 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Pathology Chromatography Gas Endocrinology Diabetes and Metabolism medicine.medical_treatment Uv spectrum Disorders of Sex Development Urine Steroid Mixed Function Oxygenases Endocrinology Adrenal Cortex Hormones Internal medicine medicine Humans Congenital adrenal hyperplasia Adrenal Hyperplasia Congenital business.industry medicine.disease Blood Human plasma Female business Retention time Metabolism Inborn Errors |
| Zdroj: | Metabolism: clinical and experimental. 14(12) |
| ISSN: | 0026-0495 |
| Popis: | From the plasma of a patient with congenital adrenal hyperplasia due to a 21-hydroxylase defect an acid-fluorescent steroid was isolated whose chromatographic mobility in 2 systems was identical to 21-deoxycortisol. The retention time observed when gas-liquid chromatography was performed on the isolated steroid (3 per cent SE-30 column) was the same as that obtained when authentic 21-deoxycortisol was chromatographed on the same column. In addition, the UV spectrum of the sample was in good agreement with that of the reference compound. The adrenal secretion of 21-deoxycortisol in this form of congenital adrenal hyperplasia has been suspected but its detection in human plasma has not been previously reported. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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