Echocardiographic Assessment of Healthy Midazolam/Butorphanol or Midazolam/Morphine-Sedated Dogs
Autor: | Beatriz Perez Floriano, Ana Elisa G. W. Marques, Geovana Possidonio, Caroliny A. Santos, Marcel G. Marques, Mariana de Andrade Ferreira, Breno Fernando Martins de Almeida |
---|---|
Rok vydání: | 2020 |
Předmět: |
040301 veterinary sciences
Butorphanol Sedation Midazolam 0403 veterinary science Dogs medicine Animals Anesthesia Small Animals Ejection fraction Morphine business.industry 0402 animal and dairy science Repeated measures design 04 agricultural and veterinary sciences Fractional shortening 040201 dairy & animal science Echocardiography medicine.symptom Isovolumic relaxation time business medicine.drug |
Zdroj: | Topics in companion animal medicine. 45 |
ISSN: | 1946-9837 |
Popis: | The purpose of this study was to assess the effects of midazolam combined with morphine or butorphanol on echocardiographic variables of healthy dogs. Twenty-four dogs of various breeds aged 34.33 ± 23.41 months and weighing 8.1 ± 4.7 kg were enrolled in the study. Subjects were randomly allocated in one of two experimental groups of sedation with intramuscular midazolam (0.3 mg/kg) combined with butorphanol (0.2 mg/kg) (GB, n = 12) or morphine (0.3 mg/kg) (GM, n = 12). Transthoracic echocardiographic examinations comprised B-Mode, M-Mode, spectral Doppler and pulsed tissue Doppler assessment. Data were recorded before sedation (TB) and 20 minutes following intramuscular administration of either sedation protocol (TS). Data were analyzed using repeated measures ANOVA followed by Tukey's posthoc test. Shortening fraction, ejection fraction, left ventricular diameter and volume did not differ among groups and time points. The A and E′ waves were decreased in GM at TS compared to TB. Isovolumic relaxation time, Ae/Ao ratio, aortic and pulmonary flows and S′ wave did not differ among time points and groups. These sedation protocols did not cause clinically relevant changes in echocardiographic variables, therefore can be used for sedation of uncooperative dogs during echocardiographic evaluation. |
Databáze: | OpenAIRE |
Externí odkaz: |