Clinical Effects of Platelet-Rich Plasma and Hyaluronic Acid as an Additional Therapy for Talar Osteochondral Lesions Treated with Microfracture Surgery
| Autor: | Baran sarıkaya, Yuksel Ersoy, Mustafa Karakaplan, Nurzat Elmalı, Cemile Ayşe Görmeli, Gökay Görmeli |
|---|---|
| Přispěvatelé: | ELMALI, NURZAT |
| Rok vydání: | 2015 |
| Předmět: |
musculoskeletal diseases
Adult Cartilage Articular Male medicine.medical_specialty Additional Therapy Visual Analog Scale Arthroplasty Subchondral medicine.medical_treatment Talus law.invention Arthroscopy chemistry.chemical_compound Randomized controlled trial law Hyaluronic acid medicine Humans Single-Blind Method Orthopedics and Sports Medicine Prospective Studies Hyaluronic Acid Saline Debridement Viscosupplements Platelet-Rich Plasma business.industry musculoskeletal system Surgery medicine.anatomical_structure chemistry Patient Satisfaction Platelet-rich plasma Orthopedic surgery Female Ankle business |
| Zdroj: | Foot & Ankle International. 36:891-900 |
| ISSN: | 1944-7876 1071-1007 |
| Popis: | Background: Osteochondral ankle injuries commonly affect the dome of the talus, and these injuries are a common cause of athletic disability. Various treatment options are available for these injuries including intra-articular hyaluronic acid (HA) and platelet-rich plasma (PRP) injections. The purpose of this study was to compare the effects of HA and PRP as adjunct therapies after arthroscopic microfracture in osteochondral lesions (OCLs) of the talus. Methods: In this prospective, randomized blinded study, 40 patients with talar OCLs in their ankle joints were treated with arthroscopic debridement and a microfracture technique. Thirteen randomly selected patients received PRP, 14 patients received HA, and the remaining 13 patients received saline as a control group. The participants were assessed using the American Orthopaedic Foot & Ankle Society (AOFAS) and visual analog pain scale (VAS) scores after a 15.3-month (range, 11-25 months) follow-up. Results: Postoperatively, all the groups exhibited significantly increased AOFAS scores and decreased VAS scores compared with their preoperative results ( P < .005). The AOFAS scores were significantly increased in the PRP group versus the HA and control groups ( P < .005), although the increased AOFAS scores in the HA group versus the control group were also significant ( P < .005). Similar to the AOFAS scores, the decrease in the VAS scores was significantly lower in the PRP group versus the HA and control groups ( P < .005). In addition, the HA group had significantly lower VAS scores than the control group ( P < .005). Conclusion: Both PRP and HA injections improved the clinical outcomes of patients who underwent operation for talar OCLs in the midterm period and can be used as adjunct therapies for these patients. Because a single dose of PRP provided better results, we recommend PRP as the primary adjunct treatment option in the talar OCL postoperative period. Level of Evidence: Level I, prospective randomized study. |
| Databáze: | OpenAIRE |
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