1% Tetracaine hydrochloride injection pure solution aerosol inhalation combined with oral administration of dyclonine hydrochloride mucilage as upper airway anesthesia for bronchoscopy: A randomized controlled trial
| Autor: | Faguang Jin, ShaoKang Dang, Wei Liu, Ning Wang, Yan Wang, GuanPing Wu, Yan Yan |
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| Rok vydání: | 2019 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male Glottis Adolescent Administration Oral law.invention 03 medical and health sciences Young Adult 0302 clinical medicine Randomized controlled trial Dyclonine Hydrochloride Bronchoscopy Double-Blind Method law Oral administration Administration Inhalation medicine Immunology and Allergy Humans Local anesthesia Anesthesia 030212 general & internal medicine Anesthetics Local Genetics (clinical) Aged Retrospective Studies Aerosols Propiophenones medicine.diagnostic_test Dose-Response Relationship Drug business.industry Middle Aged medicine.anatomical_structure 030228 respiratory system Mucilage Drug Therapy Combination Female Airway business |
| Zdroj: | The clinical respiratory journalREFERENCES. 14(2) |
| ISSN: | 1752-699X |
| Popis: | Background During the bronchoscopy process, successful passage of the tracheoscope through the glottis can affect the following procedure of bronchoscopy. Therefore, safer, more effective and less painful anesthesia methods are particularly important for the bronchoscopy success rate. Objective This study aimed to evaluate the efficacy of 1% tetracaine hydrochloride injection pure solution aerosol inhalation combined with oral administration of dyclonine hydrochloride mucilage during bronchoscopy. Methods Patients who need bronchoscopy or bronchoscope treatment were randomly assigned to two groups; group A received pure tetracaine hydrochloride injection solution (3 mL of 1% tetracaine hydrochloride) aerosol inhalation combined with oral 5 mL of dyclonine hydrochloride mucilage and group B received diluted tetracaine hydrochloride injection (3 mL of 1% tetracaine hydrochloride injection + 3 mL of sterile water for injection) aerosol inhalation combined with oral 5 mL of dyclonine hydrochloride mucilage. The anesthetic effect and adverse reactions of these groups were observed and compared. Result A total of 523 patients were randomized. The results showed that patient's tolerance, cough response, glottis opening during the bronchoscope into the glottis and the time required to the tracheoscope pass through the glottis were obviously significantly better in group A than in group B. Vital signs including blood pressure, heart rate and pulse oxygen saturation were more stable in group A than in group B. Conclusion The 1% tetracaine hydrochloride injection pure liquid aerosol inhalation combined with oral administration of dyclonine hydrochloride mucilage as upper airway anesthesia is effective and safe for bronchoscopy. This method of local anesthesia is worthy of clinical application. |
| Databáze: | OpenAIRE |
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