Is Metalloproteinase-7 Specific for Idiopathic Pulmonary Fibrosis?
| Autor: | Jin Won Huh, Won Dong Kim, Tae Sun Shim, Kyu Rae Kim, Yeon-Mok Oh, Woo Sung Kim, Sang Do Lee, Dong Soon Kim, Chae Man Lim, Y Koh |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Pathology medicine.medical_specialty Biopsy Pulmonary Fibrosis Enzyme-Linked Immunosorbent Assay Critical Care and Intensive Care Medicine Severity of Illness Index Diagnosis Differential Pathogenesis Idiopathic pulmonary fibrosis Usual interstitial pneumonia medicine Humans Lung Idiopathic interstitial pneumonia Aged Metalloproteinase business.industry Tissue Inhibitor of Metalloproteinases Middle Aged respiratory system Tissue inhibitor of metalloproteinase Prognosis medicine.disease Immunohistochemistry humanities respiratory tract diseases medicine.anatomical_structure Matrix Metalloproteinase 7 Female Lung Diseases Interstitial Cardiology and Cardiovascular Medicine business Bronchoalveolar Lavage Fluid Biomarkers Cryptogenic Organizing Pneumonia |
| Zdroj: | Chest. 133:1101-1106 |
| ISSN: | 0012-3692 |
| Popis: | Background Matrix metalloproteinase (MMP)-7 was reported to be a key molecule in the pathogenesis of idiopathic pulmonary fibrosis (IPF) based on the result of microarray analysis and knockout mice. However, the role of MMP-7 has not been determined in other types of idiopathic interstitial pneumonia (IIP). The aim of this study was to investigate the role of MMP-7 in IIP by comparing its expression in usual interstitial pneumonia (UIP) and cryptogenic organizing pneumonia (COP). Methods Levels of MMP and tissue inhibitors of metalloproteinase in BAL fluid and their expression on lung tissues were compared between normal control subjects (n = 5) and the patients with IPF (n = 6) and COP (n = 11). Results There was no significant difference in BAL fluid MMP-7 levels between UIP and COP, although it was higher in both diseases compared to normal control subjects. Furthermore, the pattern and the degree of MMP-7 expression in lung tissues were also similar in both IPF and COP, whereas MMP-2 level was higher in COP and MMP-9 level was higher in IPF. Conclusion MMP-7 seems to play an important role in the pathogenesis of not only IPF but also COP; therefore, it may not be the key factor determining the prognosis or reversibility of IIPs. |
| Databáze: | OpenAIRE |
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