Bioartificial Liver Support
| Autor: | Manuel de la Mata, Vincent G. Bain, José Luis Montero |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
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Swine medicine.medical_treatment Transplantation Heterologous Liver transplantation Bioinformatics law.invention Risk Factors law medicine Animals Humans Transplantation Homologous lcsh:RC799-869 business.industry Genetically engineered Gastroenterology Bioartificial liver device Pig endogenous retrovirus General Medicine Liver Artificial Liver regeneration Liver Regeneration Liver Transplantation Transplantation Disease Models Animal Treatment Outcome Consumer Product Safety Acute Disease Immunology Hepatocytes Support system lcsh:Diseases of the digestive system. Gastroenterology business Liver Failure Forecasting Hemodynamic instability |
| Zdroj: | Canadian Journal of Gastroenterology, Vol 15, Iss 5, Pp 313-318 (2001) |
| ISSN: | 0835-7900 |
| Popis: | Bioartificial liver support has been increasingly the focus of both basic and clinical research in an attempt to replicate the multiplicity of normal liver function. The concept is attractive because, if it is effective, patients with acute liver failure may be supported until native liver regeneration occurs or, by optimizing their condition, until liver transplantation is possible. Current bioartificial liver support systems utilize primary porcine hepatocytes or transformed human hepatocytes, which are housed within a bioreactor, through which the patient's blood or plasma is pumped in an extracorporeal circuit. The optimal source for the hepatocytes is an area of debate; however, a genetically engineered cell line may provide optimal function. Novel three-dimensional matrices that anchor the hepatocytes are being designed to mimic architectural features of the normal liver. Large multicentre, randomized, controlled trials are ongoing following several pilot studies. Serious side effects such as hemodynamic instability and immune reactions have been infrequent. Much controversy, however, surrounds the issue of possible transmission of pig endogenous retrovirus to humans, and current trials are being carefully monitored. Bioartificial liver support is a promising technology, and the results of current and planned studies are awaited with great interest. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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