Chronic exposure to low mercury chloride concentration induces object recognition and aversive memories deficits in rats
| Autor: | Pâmela Billig Mello-Carpes, Niége Alves, Wellinghton Barros, Dalton Valentim Vassallo, Danize Aparecida Rizzetti, Giulia Alessandra Wiggers, Ivan Izquierdo, Sidnei Borges, Franck Maciel Peçanha |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Pain Threshold Chronic exposure medicine.medical_specialty Elevated plus maze Time Factors medicine.medical_treatment chemistry.chemical_element Inhibitory postsynaptic potential Chloride Open field Toxicology Developmental Neuroscience Internal medicine Avoidance Learning medicine Animals Rats Wistar Maze Learning Saline Recognition memory Memory Disorders Dose-Response Relationship Drug Recognition Psychology Rats Mercury (element) Disease Models Animal Endocrinology chemistry Mercuric Chloride Exploratory Behavior Psychology Developmental Biology medicine.drug |
| Zdroj: | International Journal of Developmental Neuroscience. 31:468-472 |
| ISSN: | 1873-474X 0736-5748 |
| DOI: | 10.1016/j.ijdevneu.2013.05.009 |
| Popis: | This work examines the effects of chronic exposure to low inorganic mercury (mercury chloride, HgCl2) concentration on the recognition and aversive memories. Forty male Wistar rats were divided into 4 groups treated during 30 or 60 days with saline (control) or HgCl2 doses. After treated the animals were tested considering object recognition and inhibitory avoidance behavioral memory paradigms. Elevated plus maze, open field and tail flick tests were used to assess anxiety, locomotor and exploratory activity and pain thresholds. Only exposure for 60 days to HgCl2 induced in memory deficits quantified in the object recognition task. In the inhibitory avoidance all the animals exposed to mercury (for 30 or 60 days) presented worst performance than control animals. Our results suggest that chronic exposure to low mercury chloride concentrations impairs memory formation. |
| Databáze: | OpenAIRE |
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