Phase I clinical study of a static magnetic field combined with anti-neoplastic chemotherapy in the treatment of human malignancy: initial safety and toxicity data
| Autor: | Joanne Harrington, Joseph R. Salvatore, Thomas Kummet |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Oncology
Male medicine.medical_specialty Physiology medicine.medical_treatment Biophysics Antineoplastic Agents Malignancy Radiation Dosage Risk Assessment Clinical study Leukocyte Count Magnetics Electromagnetic Fields White blood cell Internal medicine Neoplasms Antineoplastic Combined Chemotherapy Protocols Toxicity Tests medicine Humans Radiology Nuclear Medicine and imaging Anti neoplastic Cyclophosphamide Aged Chemotherapy Toxicity data business.industry Platelet Count Cancer Dose-Response Relationship Radiation General Medicine Middle Aged medicine.disease Combined Modality Therapy Surgery medicine.anatomical_structure Doxorubicin Vincristine Toxicity Prednisone Female business |
| Zdroj: | Bioelectromagnetics. 24(7) |
| ISSN: | 0197-8462 |
| Popis: | We have completed the lowest level of exposure in a Phase I study, designed to establish the safety and toxicity of the combination of a static magnetic field (SMF) and antineoplastic chemotherapy in patients with advanced malignancy. The SMF application is carefully controlled by applying the magnet to the patient only in our clinic during chemotherapy administration. No increase in the severity of chemotherapy toxicity as measured by white blood cell count and platelet count was seen in the participants exposed to SMF compared to the historical control subjects. These data have permitted the next group of subjects to be treated at the next dose level. |
| Databáze: | OpenAIRE |
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