A Thrombectomy Model Based on Ex Vivo Whole Human Brains
| Autor: | Luis E. Savastano, Jorge L Arturo Larco, R Kadirvel, A Shahid, S Madhani, Waleed Brinjikji, R.A. Quinton, David F. Kallmes, Yang Liu |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Clinical Sciences Bioengineering Embolization Internal medicine Occlusion medicine Humans Radiology Nuclear Medicine and imaging Thrombectomy Interventional medicine.diagnostic_test business.industry Neurosciences Brain Thrombosis Embolization Therapeutic Stroke Nuclear Medicine & Medical Imaging Treatment Outcome Angiography Cardiology Neurology (clinical) Therapeutic business Ex vivo Cerebral angiography |
| Zdroj: | AJNR. American journal of neuroradiology, vol 42, iss 11 AJNR Am J Neuroradiol |
| ISSN: | 1936-959X 0195-6108 |
| DOI: | 10.3174/ajnr.a7291 |
| Popis: | BACKGROUND AND PURPOSE: The persistent challenges in thrombectomy for large-vessel occlusion, such as suboptimal complete recanalization and first-pass effect imply an insufficient understanding of the artery-clot-device interaction. In this study, we present a thrombectomy model using fresh human brains, which can capture the artery-clot-device interaction through concurrent transmural and angiographic visualizations. MATERIALS AND METHODS: Fresh nonfrozen whole adult human brains were collected and connected to a customized pump system tuned to deliver saline flow at a physiologic flow rate and pressure. Angiography was performed to verify the flow in the anterior-posterior and vertebrobasilar circulations and collaterals. Large-vessel occlusion was simulated by embolizing a radiopaque clot analog. Thrombectomy was tested, and the artery-clot-device interactions were recorded by transmural and angiographic videos. RESULTS: Baseline cerebral angiography revealed excellent penetration of contrast in the anterior-posterior and vertebrobasilar circulations without notable arterial cutoffs and with robust collaterals. Small branches ( |
| Databáze: | OpenAIRE |
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