Daptomycin-β-Lactam Combinations in a Rabbit Model of Daptomycin-Nonsusceptible Methicillin-Resistant Staphylococcus aureus Endocarditis
| Autor: | Li Basuino, Stephanie M. Hamilton, Henry F. Chambers, Pamela A. Moise, Eun Ju Choo |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Ertapenem Methicillin-Resistant Staphylococcus aureus Carbapenem medicine.drug_class 030106 microbiology Cephalosporin Microbial Sensitivity Tests medicine.disease_cause beta-Lactams Microbiology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Daptomycin polycyclic compounds Medicine Endocarditis Animals Pharmacology (medical) Experimental Therapeutics 030212 general & internal medicine Pharmacology business.industry Ceftriaxone Endocarditis Bacterial biochemical phenomena metabolism and nutrition medicine.disease bacterial infections and mycoses Methicillin-resistant Staphylococcus aureus Cephalosporins Infectious Diseases chemistry Staphylococcus aureus lipids (amino acids peptides and proteins) Rabbits business medicine.drug |
| Zdroj: | Antimicrobial agents and chemotherapy. 60(7) |
| ISSN: | 1098-6596 |
| Popis: | Beta-lactams enhance the in vitro activity of daptomycin against methicillin-resistant strains of Staphylococcus aureus . Experiments were performed in a rabbit model of aortic valve endocarditis caused by methicillin-resistant daptomycin-nonsusceptible S. aureus strain CB5054 to determine if a cephalosporin, ceftriaxone, administered as a once-daily dose of 100 mg/kg of body weight, or a carbapenem, ertapenem, administered as a once-daily dose of 40 mg/kg, improved the efficacy of daptomycin, administered as a once-daily dose of 12 mg/kg. Daptomycin was ineffective alone in reducing organism densities compared to untreated controls in vegetations and spleen, but densities were 1.4 log 10 CFU/g lower in kidney. The combination of daptomycin plus ceftriaxone or daptomycin plus ertapenem reduced bacterial densities in all tissues compared to single agents, with 0.6 to 1.0 log 10 CFU/g fewer organisms in vegetations, 1.5 to 2.5 log 10 CFU/g fewer organisms in spleen, and 1.8 to 2.5 log 10 CFU/g fewer organisms in kidney, although differences were statistically significant only in spleen for daptomycin plus ceftriaxone and in kidney for daptomycin plus ertapenem. Drug exposures in rabbits were less than those achievable in humans, which may have limited the in vivo activity, particularly in vegetations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|