Characterization of enteroglial cells and denervation process in chagasic patients with and without megaesophagus
| Autor: | Ricardo Toshio Fujiwara, Débora d'Ávila Reis, Sheila Jorge Adad, Rodrigo Corrêa Oliveira, Rodolfo Duarte Nascimento, Alexandre B. M. da Silveira, André de Souza Lisboa, Michelle A. R. Freitas |
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| Rok vydání: | 2009 |
| Předmět: |
Chagas disease
Pathology medicine.medical_specialty Inflammation Biology Enteric Nervous System Pathology and Forensic Medicine Esophagus parasitic diseases Glial Fibrillary Acidic Protein medicine Esophagitis Humans Chagas Disease Trypanosoma cruzi Denervation Glial fibrillary acidic protein S100 Proteins Megaesophagus Middle Aged medicine.disease biology.organism_classification Esophageal Achalasia medicine.anatomical_structure biology.protein Enteric nervous system medicine.symptom Neuroglia |
| Zdroj: | Human pathology. 41(4) |
| ISSN: | 1532-8392 |
| Popis: | Chagas disease is caused by infestation with the parasite Trypanosoma cruzi, and some patients who are serologically positive develop chronic megaesophagus, whereas others are symptom-free. Gastrointestinal form of Chagas disease involves an inflammatory invasion of the enteric plexuses and degeneration of enteric neurons and previous works related that enteroglial cells would be involved in enteric inflammatory responses. Because of this, the aims of this study were to determine the relation of enteroglial cells with the denervation process in chagasic patients with and without megaesophagus and seronegative individuals. Our results indicated that the innervation of the esophageal muscle was substantially reduced in patients with megaesophagus, but asymptomatic seropositive subjects were not different to seronegative controls. Besides, patients with megaesophagus had significant decreased of enteroglial cells labeled with S-100 and glial fibrillary acidic protein, whereas patients without megaesophagus presented an increased of both labels. We believe that enteroglial cells would operate a mechanism of defense in the enteric nervous system against the Trypanosoma cruzi infection, which could prevent the organ denervation and preserve the esophagus function. |
| Databáze: | OpenAIRE |
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