Superficial and Deep Macula Vessel Density in Healthy, Glaucoma Suspect, and Glaucoma Eyes
| Autor: | Linda M. Zangwill, Adeleh Yarmohammadi, Elham Ghahari, Jasmin Rezapour, Christopher Bowd, Takuhei Shoji, Nevin W. El-Nimri, James A. Proudfoot, Patricia Isabel C. Manalastas, Rafaella C. Penteado, Robert N. Weinreb, Sasan Moghimi, Huiyuan Hou, Eren Ekici |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Retinal Ganglion Cells
medicine.medical_specialty Capillary plexus genetic structures Clinical Sciences Glaucoma Neurodegenerative Ophthalmology & Optometry Article 03 medical and health sciences Nerve Fibers 0302 clinical medicine Vessel density Clinical Research Ophthalmology medicine Humans Macula Lutea Fluorescein Angiography Tomography Eye Disease and Disorders of Vision Intraocular Pressure screening and diagnosis Receiver operating characteristic Preperimetric glaucoma business.industry superficial capillary plexus Retinal Vessels Optical coherence tomography angiography Glaucoma suspect OCT-A medicine.disease deep capillary plexus eye diseases Ganglion Detection Open-Angle Cross-Sectional Studies medicine.anatomical_structure Optical Coherence 030221 ophthalmology & optometry Biomedical Imaging sense organs Visual Fields business 030217 neurology & neurosurgery 4.2 Evaluation of markers and technologies |
| Zdroj: | J Glaucoma Journal of glaucoma, vol 30, iss 6 |
| Popis: | PRECIS Macular superficial capillary plexus (SCP) vessel density is more informative than deep capillary plexus (DCP) vessel density for the detection of glaucoma. PURPOSE The purpose of this study was to characterize optical coherence tomography angiography macular SCP and projection-resolved DCP vessel densities and compare their diagnostic accuracies with ganglion cell complex (GCC) thickness in healthy, glaucoma suspect, and glaucoma eyes. MATERIALS AND METHODS Sixty-eight eyes of 44 healthy subjects, 26 eyes of 16 preperimetric glaucoma suspects, and 161 eyes of 124 glaucoma patients from the Diagnostics Innovations in Glaucoma Study with good quality high-density 6×6 mm2 macula optical coherence tomography angiography images were included. The diagnostic accuracy of SCP vessel density, projection-resolved DCP vessel density and GCC thickness were compared among groups. RESULTS Mean whole image vessel density (wiVD; % of area occupied by vessels containing flowing blood) in the SCP layer was highest in healthy eyes (49.7%), followed by glaucoma suspect eyes (46.0%), and glaucoma eyes (40.9%) (P |
| Databáze: | OpenAIRE |
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