Role of Pax Genes in Eye Evolution
| Autor: | Michael Daube, Lidia Kos, Markus Noll, Joram Piatigorsky, Erich Frei, Zbynek Kozmik, Barbara Norman, Larry J. Dishaw |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Genetics
animal structures Evolution of the eye genetic structures Tripedalia cystophora Pax genes Simple eye in invertebrates Cell Biology Biology biology.organism_classification eye diseases General Biochemistry Genetics and Molecular Biology Crystallin Eye development Homeobox sense organs PAX6 Molecular Biology Developmental Biology |
| Zdroj: | Developmental Cell. 5:773-785 |
| ISSN: | 1534-5807 |
| DOI: | 10.1016/s1534-5807(03)00325-3 |
| Popis: | PaxB from Tripedalia cystophora , a cubomedusan jellyfish possessing complex eyes (ocelli), was characterized. PaxB , the only Pax gene found in this cnidarian, is expressed in the larva, retina, lens, and statocyst. PaxB contains a Pax2/5/8-type paired domain and octapeptide, but a Pax6 prd -type homeodomain. Pax2/5/8-like properties of PaxB include a DNA binding specificity of the paired domain, activation and inhibitory domains, and the ability to rescue spa pol , a Drosophila Pax2 eye mutant. Like Pax6, PaxB activates jellyfish crystallin and Drosophila rhodopsin rh6 promoters and induces small ectopic eyes in Drosophila . Pax6 has been considered a "master" control gene for eye development. Our data suggest that the ancestor of jellyfish PaxB, a PaxB-like protein, was the primordial Pax protein in eye evolution and that Pax6-like genes evolved in triploblasts after separation from Cnidaria, raising the possibility that cnidarian and sophisticated triploblastic eyes arose independently. |
| Databáze: | OpenAIRE |
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