Use of anti-diabetic drugs and glycaemic control in type 2 diabetes—The Hong Kong Diabetes Registry
| Autor: | Chun-Chung Chow, Sau-chu Chiang, Clive S. Cockram, Ronald C.W. Ma, Xilin Yang, Gary T.C. Ko, Risa Ozaki, Peter C.Y. Tong, Alice P.S. Kong, Juliana C.N. Chan, Wing-Yee So |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Population Type 2 diabetes Cohort Studies Young Adult chemistry.chemical_compound Endocrinology Asian People Diabetes mellitus Internal medicine Internal Medicine Humans Hypoglycemic Agents Insulin Medicine Registries Treatment Failure education Aged Glycemic Aged 80 and over Glycated Hemoglobin education.field_of_study business.industry General Medicine Middle Aged medicine.disease Surgery Treatment Outcome Diabetes Mellitus Type 2 chemistry Cohort Hong Kong Drug Therapy Combination Female Glycated hemoglobin business Cohort study |
| Zdroj: | Diabetes Research and Clinical Practice. 82:346-352 |
| ISSN: | 0168-8227 |
| DOI: | 10.1016/j.diabres.2008.09.006 |
| Popis: | In this report, we examined the usage of anti-diabetic treatments including oral anti-diabetic drug (OAD) and/or insulin and their combination from baseline data of a consecutive cohort of 7549 Chinese type 2 diabetic subjects in the Hong Kong Diabetes Registry. Pattern of usage of anti-diabetic treatment and corresponding glycemic control was analyzed. OAD failure was defined as the need to add insulin to maintain glycemic target (glycated hemoglobin, HbA(1c) level7%) with or without continuation of OAD. There were 4109 [54.4%] women and 3440 [45.6%] men (age: median 57.0 years; range 13-92 years). The mean HbA(1c) level was 7.7+/-1.8% with 39.7% attaining glycemic target. Long disease duration was associated with more complex regimens and the respective rates of OAD failure requiring insulin use were 23.7%, 39.3%, 57.1% and 75.9% in those with disease duration5 years, 5-9.9 years, 10-19.9 years andor =20 years (p0.001). In conclusion, in a clinic-based type 2 diabetic population, 39.7% attained glycemic target with HbA(1c)7%. Long disease duration and complexity of treatment regimens were associated with suboptimal glycemic control. Early intensification of therapy and system improvement are needed to enhance the effectiveness of these drugs in clinical practice. |
| Databáze: | OpenAIRE |
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