Mapping hypercapnia-induced cerebrovascular reactivity using BOLD MRI

Autor: F. H. R. van der Zande, Walter H. Backes, Paul A. M. Hofman
Rok vydání: 2004
Předmět:
Zdroj: Neuroradiology. 47:114-120
ISSN: 1432-1920
0028-3940
DOI: 10.1007/s00234-004-1274-3
Popis: Severe carotid artery stenosis or occlusion may put patients at risk for ischaemic stroke. Reduced cerebrovascular reserve capacity is a possible indicator of an imminent ischaemic event and can be determined by assessment of cerebrovascular reactivity to a vasodilative stimulus. However, little is known about the distribution of cerebrovascular reactivity in healthy individuals. In 13 healthy volunteers, dynamic T2* MR images, acquired at alternating inspiratory pCO2 levels, showed a high percentage of signal change in grey matter, with a strong linear correlation with end-tidal pCO2. The mean percentages of signal change for grey and white matter were 5.9 +/- 1.2% and 1.9 +/- 0.5%, respectively. The mean time lag between CO2 stimulus and haemodynamic response was 15 +/- 4 s for grey matter and 180 +/- 12 s for white matter. Parameter mapping revealed a hemispherically symmetrical and homogeneous distribution of cerebrovascular reactivity over the entire grey matter. These findings indicate that it may be feasible to detect exhausted cerebrovascular autoregulation in patients with a compromised cerebral vasculature.
Databáze: OpenAIRE
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