Resection margins and local recurrences of impalpable breast cancer: Comparison between radioguided occult lesion localization (ROLL) and radioactive seed localization (RSL)

Autor: Katja Hukkinen, Johanna Mattson, Marjut Leidenius, Laura Niinikoski, Päivi Heikkilä, Päivi Vaara, Tuomo J. Meretoja, Aleksandar Voynov
Přispěvatelé: HUS Comprehensive Cancer Center, Helsinki University Hospital Area, Department of Oncology, Clinicum, HUS Medical Imaging Center, Department of Diagnostics and Therapeutics, II kirurgian klinikka, Department of Surgery, HUSLAB, Department of Pathology, Medicum
Rok vydání: 2019
Předmět:
medicine.medical_treatment
Mastectomy
Segmental
Cohort Studies
Hospitals
University
Breast cancer
0302 clinical medicine
3123 Gynaecology and paediatrics
Local recurrence
Breast-conserving surgery
030212 general & internal medicine
Lymph node
Finland
Palpation
Surgical margins
Carcinoma
Ductal
Breast
WIRE-GUIDED LOCALIZATION
Margins of Excision
General Medicine
Middle Aged
CONSERVING SURGERY
Prognosis
3. Good health
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
Female
Radiology
Ultrasonography
Mammary
medicine.symptom
Adult
Reoperation
medicine.medical_specialty
Radioactive seed
3122 Cancers
Breast Neoplasms
Risk Assessment
Disease-Free Survival
Resection
Lesion
03 medical and health sciences
Breast conserving surgery
medicine
Humans
Neoplasm Invasiveness
Radionuclide Imaging
Aged
Neoplasm Staging
Retrospective Studies
Radioactive seed localization
business.industry
Radioguided occult lesion localization
Retrospective cohort study
medicine.disease
Occult
Survival Analysis
Carcinoma
Intraductal
Noninfiltrating
NODES
Surgery
Biopsy
Large-Core Needle
Neoplasm Recurrence
Local
business
Zdroj: Breast (Edinburgh, Scotland). 47
ISSN: 1532-3080
Popis: The aim of this retrospective study is to compare surgical margins, reoperation rates and local recurrences after breast conserving surgery (BCS) using radioguided occult lesion localization (ROLL) or radioactive seed localization (RSL).We reviewed 744 consecutive patients with impalpable primary invasive breast cancer who underwent BCS at Helsinki University Hospital between 2010 and 2012. ROLL was used in our unit until October 31st, 2011; from November 1st we changed localization method to RSL.318 patients underwent ROLL and 426 RSL. Patients in the RSL group had more often multifocal (p = 0.013) tumours. No statistically significant differences were found regarding tumour size, specimen weight, histology or grade of tumours or lymph node status. 42 (5.6%) patients were reoperated because of insufficient margins, 13 (4.1%) in the ROLL group and 29 (6.8%) in the RSL group. The reoperation rate was not different between the groups either in the univariable analysis (p = 0.112) or in the multivariable binary logistic regression analysis (p = 0.204). Risk factors for reoperations were multifocality of the tumour (p 0.001), extensive intraductal component (p 0.001), larger tumour size (p = 0.011), and smaller specimen weight (p = 0.014). The median follow-up time in the ROLL group was 81 (8-94) months and 64 (3-73) months in the RSL group. The five-year local recurrence-free survival (LRFS) estimates for ROLL and RSL groups were 98.0% and 99.4%, respectively (log-rank test, p = 0.323).Reoperation rates and LRFS were comparable for ROLL and RSL in patients with impalpable breast cancer treated with BCS.
Databáze: OpenAIRE
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