Antiulcer activity of ethanol leaf extract of Cassia fistula

Autor:	Kuppannan Gobianand, Sivanesan Karthikeyan
Rok vydání:	2010
Předmět:	Male Cassia Pharmaceutical Science Pharmacology Fucose Ranitidine Lipid peroxidation chemistry.chemical_compound Random Allocation Drug Discovery medicine Animals Hexose Stomach Ulcer Rats Wistar chemistry.chemical_classification Ethanol biology Dose-Response Relationship Drug Chemistry Plant Extracts General Medicine Carbohydrate biology.organism_classification Pylorus Anti-Ulcer Agents digestive system diseases Rats Plant Leaves medicine.anatomical_structure Complementary and alternative medicine Biochemistry Molecular Medicine Lipid Peroxidation medicine.drug
Zdroj:	Pharmaceutical biology. 48(8)
ISSN:	1744-5116
Popis:	The ethanol leaf extract (ELE) of Cassia fistula Linn. (Caesalpinaceae) was evaluated for antiulcer activity against pylorus ligation-induced gastric ulcer. Ranitidine (30 mg/kg b.w.) and ELE at doses of 250, 500, and 750 mg/kg b.w. were administered orally in different groups of rats (n = 6), 1 h prior to pyloric ligation. Four hours after pyloric ligation, the gastric juice was collected for evaluation of various parameters. The antiulcer activity of ELE was evidenced by the significant attenuation of gastric volume, pH, free acidity, and total acidity in the gastric juice of pyloric-ligated rats in a dose-dependent manner, and this protective effect could be due to strengthening of the mucosal defense mechanism. ELE pre-treatment significantly attenuated the fall in status of sialic acid and fucose accompanied by an increase in hexose, hexosamine, total non-amino polysaccharide, total carbohydrate, and C:P ratio in the gastric juice of pylorus-ligated rats, and this effect could be due to protection of the mucosal barrier system. ELE pre-treatment significantly prevented the increase in LPO and SOD accompanied by a fall in CAT, in the gastric juice of pyloric-ligated rats. This protective ability of ELE against pylorus ligation-induced gastric ulcer could be attributed to its free radical scavenging and antioxidant properties. Higher doses of ELE (750 mg/kg b.w.) produced maximum antiulcer activity comparable to ranitidine treatment. In essence, the antiulcer activity of ELE could be attributed to (i) a decrease in gastric acid secretion, (ii) protection of the mucosal barrier and restoration of mucosal secretions, (iii) inhibition of free radical generation or prevention of lipid peroxidation, and (iv) free radical scavenging or antioxidant properties.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe99310c1fa0ceb1ecf7af869cfcb8c3 https://pubmed.ncbi.nlm.nih.gov/20673173 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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