Berberine alleviates adipose tissue fibrosis by inducing AMP-activated kinase signaling in high-fat diet-induced obese mice
| Autor: | Yanyin Hua, Xiao Ye, Lijun Wang, Yingxiang Song |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Berberine Anti-Inflammatory Agents Adipose tissue Type 2 diabetes AMP-Activated Protein Kinases Diet High-Fat 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Fibrosis Internal medicine medicine Animals Obesity Pharmacology Chemistry AMPK General Medicine medicine.disease Mice Inbred C57BL Disease Models Animal 030104 developmental biology Endocrinology Adipose Tissue 030220 oncology & carcinogenesis Phosphorylation Signal Transduction |
| Zdroj: | Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 105 |
| ISSN: | 1950-6007 |
| Popis: | Adipose tissue fibrosis is a novel mechanism for the development of obesity related insulin resistance. Berberine (BBR) has been shown to relieve several metabolic disorders, including obesity and type 2 diabetes. However, the effects of BBR on obesity related adipose fibrosis remain poorly understood. The objective of this study was to assess the effects of BBR on adipose tissue fibrosis in high fat diet (HFD)-induced obese mice. The results showed that BBR reduced animal body weight and significantly improved glucose tolerance in HFD mice. In addition, BBR treatment markedly attenuated collagen deposition and reversed the up-regulation of fibrosis associated genes in the adipose tissue of HFD mice. Moreover, BBR treatment activated AMP-activated kinase signaling and reduced TGF-β1 and Smad3 phosphorylation. Of note, the inhibitory effects of BBR on adipose tissue fibrosis were significantly blocked by AMPK inhibition with compound C, an AMPK inhibitor. Macrophage infiltration and polarization induced by HFD were also reversed after BBR administration. These findings suggest that BBR displays beneficial effects in the treatment of obesity, in part via improvement of adipose tissue fibrosis. |
| Databáze: | OpenAIRE |
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