Immune System Activation in Perioperative Thrombectomy Patients: Preliminary Retrospective Study
| Autor: | Abdulnasser Alhajeri, Keith R. Pennypacker, Olga A. Vsevolozhskaya, Justin F. Fraser, Skylar Trott |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Brain Ischemia Leukocyte Count Young Adult 03 medical and health sciences Postoperative Complications 0302 clinical medicine Immune system White blood cell Internal medicine medicine Humans Perioperative Period Aged Retrospective Studies Thrombectomy Aged 80 and over Sex Characteristics business.industry Cerebral infarction Retrospective cohort study Wbc count Perioperative Thrombolysis Middle Aged medicine.disease Stroke Mechanical thrombectomy Treatment Outcome medicine.anatomical_structure Immune System 030220 oncology & carcinogenesis Cardiology Female Surgery Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | World Neurosurgery. 128:e966-e969 |
| ISSN: | 1878-8750 |
| Popis: | Background Ischemic stroke is a devastating condition resulting in significant morbidity. Mechanical thrombectomy is now standard for large vessel occlusive stroke. Neuroinflammation is known to play important roles in ischemic stroke. Our aims were to examine our thrombectomy procedures and preliminarily examine systemic immune response in relation to thrombectomy changes. Methods A retrospective review was conducted on mechanical thrombectomy cases from July 2011 through December 2015. Primary outcomes were time to recanalization, final Thrombolysis in Cerebral Infarction score, procedural complications, National Institutes of Health Stroke Scale improvement, and changes in white blood cell (WBC) count. Results One-hundred and twenty-nine procedures were performed. We found a significant difference between WBC count on admission and WBC count post thrombectomy day 1 for patients with >90 minutes to recanalization (P = 0.006107). There was a positive association between WBC change and absolute National Institutes of Health Stroke Scale change among females (P = 0.0273) but not among males. Conclusions Overall, we found that systemic immune response has close relationships with speed of recanalization and preliminarily may shift differently on the basis of sex. |
| Databáze: | OpenAIRE |
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