Synthesis and comparison of crosslinked peptide nanoparticles based on diphenylalanine derivatives
| Autor: | Betül Bozdoğan, Öznur Akbal, Tayfun Vural, Emir Baki Denkbaş |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Morphology (linguistics) Materials science Polymers and Plastics Nanoparticle Peptide 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Surfaces Coatings and Films Nanomaterials chemistry.chemical_compound chemistry Chemical engineering Amide Polymer chemistry Materials Chemistry Surface charge Glutaraldehyde Diphenylalanine 0210 nano-technology |
| Popis: | Self-assembly is a mechanism that creates novel nanomaterials with amplified properties but with stability challenges. In this report, highly stable and biocompatible anionic zwitterionic diphenylalanine nanoparticles (ZFFNPs), which are novel for the literature, are demonstrated. ZFF was crosslinked with glutaraldehyde (GA) and self-assembled into nanoparticles in a self-assembly mechanism like that for diphenylalaninamide nanoparticles (FFANPs). Also, ZFFNPs were compared with FFANPs in aspects of morphology, surface charge, stability, and cytotoxicity. ZFFNPs demonstrate a spherical morphology and homogenicity like FFANPs, but while ZFFNPs have negative surface groups (carboxyl), FFANPs contain polar surface groups (amide). While ZFFNPs exhibit a high stability in extremely acidic environments (pH 3–5), AFFNPs show stability in a wide pH range (pH 4–10). Both NPs are nontoxic and biocompatible. These novel anionic ZFFNPs have great promise for potential utilization in biomedical applications. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 135, 45930. |
| Databáze: | OpenAIRE |
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