Adapted Murine Sepsis Score: Improving the Research in Experimental Sepsis Mouse Model

Autor: Maicon Machado Sulzbacher, Lucas Machado Sulzbacher, Felipe Rafael Passos, Bruna Letícia Endl Bilibio, Kauana de Oliveira, Wellington Felipe Althaus, Matias Nunes Frizzo, Mirna Stela Ludwig, Ivana Beatrice Mânica Da Cruz, Thiago Gomes Heck
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: BioMed Research International
BioMed Research International, Vol 2022 (2022)
ISSN: 2314-6133
DOI: 10.1155/2022/5700853
Popis: The Murine Sepsis Score (MSS) is used to assess the severity of sepsis in rats and mice based on observational characteristics. The quantitative variables of glycemia, body weight, and temperature are predictors of severity in experimental models of sepsis. Therefore, our study sought to adapt the MSS with the same variables to indicate earlier the severity of the disease in murine models of the disease. Sepsis mice presented hypoglycemia, weight loss, and hypothermia. Therefore, these variables were included in the Adapted Murine Sepsis Score (A-MSS). The A-MASS presented 100% specificity and 87.5% sensibility been able to differentiate the early sepsis symptoms and its severity. The A-MSS allows an early and more complete diagnosis of sepsis in mice and might be considered as a procedure to improve the analysis of systemic sepsis dysfunction in murine experimental models.
Databáze: OpenAIRE
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