Developmental changes of the contingent negative variation in migraine and healthy children
| Autor: | Ulrich Stephani, Michael Siniatchkin, Anne Jonas, Andreas van Baalen, Huelya Baki, Wolf-Dieter Gerber |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Longitudinal study Aging Neurology Time Factors Adolescent Original Migraine Disorders Clinical Neurology Contingent Negative Variation Audiology Electroencephalography Severity of Illness Index Maturation medicine Humans Longitudinal Studies Habituation Child Habituation Psychophysiologic Evoked Potentials Migraine Cerebral Cortex medicine.diagnostic_test business.industry Electrodiagnosis General Medicine medicine.disease Contingent negative variation Anesthesiology and Pain Medicine medicine.anatomical_structure Cerebral cortex Chronic Disease Disease Progression Female Neurology (clinical) Headaches medicine.symptom business Neuroscience |
| Zdroj: | The Journal of Headache and Pain |
| ISSN: | 1129-2377 1129-2369 |
| Popis: | It has been hypothesized that abnormalities of information processing in migraine may be attributed to impairment of cerebral maturation. However, the most evidences for this hypothesis have come from cross-sectional studies during childhood. We performed a longitudinal study and recorded contingent negative variation (CNV), an event-related slow cortical potential, in migraine children (n = 27) and age-matched healthy individuals (n = 23) in 1998 and 8 years later (2006). Amplitudes of all CNV components were reduced and habituation of the initial CNV (iCNV) increased in the observed time. However, the reduction of the iCNV amplitude was more pronounced in migraine patients who were in remission in 2006 and in healthy subjects and less pronounced in migraineurs with persisting headaches. Patients with the worsened migraine demonstrated the most pronounced loss of iCNV habituation in 1998 and significantly increased iCNV amplitudes in 2006. This longitudinal study supports the hypothesis of impaired cerebral maturation in migraine and shows that migraine manifestation is a key factor interfering with the natural maturation process of central information processing. |
| Databáze: | OpenAIRE |
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