HLA class II alleles of susceptibility and protection in Brazilian and Dutch pemphigus foliaceus
| Autor: | Adriana Maria Porro, Hendri H. Pas, Jane Tomimori, L de Sena Nogueira Maehara, E V C Marcos, Ilja M. Nolte, Marcel F. Jonkman, S. Ura, F C De-Souza-Santana |
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| Přispěvatelé: | Life Course Epidemiology (LCE), Microbes in Health and Disease (MHD), Translational Immunology Groningen (TRIGR) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
FOGO-SELVAGEM Heterozygote Letter GENETICS Dermatology Disease 03 medical and health sciences 0302 clinical medicine Gene Frequency Medicine Humans Genetic Predisposition to Disease Allele education skin and connective tissue diseases Pemphigus foliaceus Netherlands education.field_of_study VULGARIS integumentary system business.industry Homozygote Histocompatibility Antigens Class II Heterozygote advantage medicine.disease Ashkenazi jews Pemphigus 030104 developmental biology Cross-Sectional Studies Desmoglein 1 Desmoglein 3 Immunology business Brazil 030215 immunology |
| Zdroj: | The British journal of dermatology, 178(3), e212-e214. Wiley |
| ISSN: | 0007-0963 |
| Popis: | Pemphigus foliaceus (PF) is a worldwide chronic autoimmune bullous disease targeting desmoglein 1 (Dsg 1) on epithelial cell surface of skin and mucous membranes, causing lesions in skin but sparing mucosa, since the latter contain compensating desmoglein 3(1) . Several environmental triggers for the autoimmune reaction have been imputed, such as drugs, ultraviolet radiation and mercurium. Human leucocyte antigens class II (HLA-DR4) alleles were linked to the disease in Ashkenazi Jews and other populations(2) . For endemic pemphigus foliaceus in Brazil, named fogo selvagem (FS), HLA-DRB1*04 was shown to have a relative risk >14 for the disease(3) . This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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