Interdependence of tetrapyrrole metabolism, the generation of oxidative stress and the mitigative oxidative stress response
| Autor: | Beronda L. Montgomery, Andrea W. U. Busch |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Light Signal Transduction
Light Iron Clinical Biochemistry Cell Protoporphyrins Review Article Heme Biology Photosynthesis medicine.disease_cause Cyanobacteria Tetrapyrrole Biochemistry Redox chemistry.chemical_compound Detoxification High light Botany medicine lcsh:QH301-705.5 Peroxidase chemistry.chemical_classification Reactive oxygen species lcsh:R5-920 Superoxide Dismutase Organic Chemistry ROS Plants Catalase 3. Good health Cell biology medicine.anatomical_structure chemistry Tetrapyrroles lcsh:Biology (General) Oxidative stress Phytochrome Reactive Oxygen Species lcsh:Medicine (General) Oxidation-Reduction Homeostasis |
| Zdroj: | Redox Biology, Vol 4, Iss C, Pp 260-271 (2015) Redox Biology |
| ISSN: | 2213-2317 |
| DOI: | 10.1016/j.redox.2015.01.010 |
| Popis: | Tetrapyrroles are involved in light harvesting and light perception, electron-transfer reactions, and as co-factors for key enzymes and sensory proteins. Under conditions in which cells exhibit stress-induced imbalances of photosynthetic reactions, or light absorption exceeds the ability of the cell to use photoexcitation energy in synthesis reactions, redox imbalance can occur in photosynthetic cells. Such conditions can lead to the generation of reactive oxygen species (ROS) associated with alterations in tetrapyrrole homeostasis. ROS accumulation can result in cellular damage and detrimental effects on organismal fitness, or ROS molecules can serve as signals to induce a protective or damage-mitigating oxidative stress signaling response in cells. Induced oxidative stress responses include tetrapyrrole-dependent and -independent mechanisms for mitigating ROS generation and/or accumulation. Thus, tetrapyrroles can be contributors to oxidative stress, but are also essential in the oxidative stress response to protect cells by contributing to detoxification of ROS. In this review, we highlight the interconnection and interdependence of tetrapyrrole metabolism with the occurrence of oxidative stress and protective oxidative stress signaling responses in photosynthetic organisms. Graphical abstract Highlights • Tetrapyrroles are involved in light sensing and oxidative stress mitigation. • Reactive oxygen species (ROS) can form upon light exposure of free tetrapyrroles. • Tetrapyrrole homeostasis must be tightly regulated to avoid oxidative stress. • ROS can result in cellular damage or oxidative stress signaling in cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|