Yacon (Smallanthus sonchifolius)-derived fructooligosaccharides improves the immune parameters in the mouse
| Autor: | Wirla Maria da Silva Cunha Tamashiro, Grethel Teresa Choque Delgado, Rodolfo Thomé, D. L. Gabriel, Glaucia Maria Pastore |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_treatment
Endocrinology Diabetes and Metabolism Interleukin-1beta Anti-Inflammatory Agents Oligosaccharides Spleen Fructose Biology Asteraceae Nitric oxide Proinflammatory cytokine Immunomodulation chemistry.chemical_compound Feces Mice Immune system Endocrinology Fructooligosaccharides medicine Animals Intestinal Mucosa Mice Inbred BALB C Nutrition and Dietetics Plant Extracts Fructooligosaccharide Macrophages Interleukin Immunoglobulin A Prebiotics medicine.anatomical_structure Cytokine chemistry Yacon root Immunology Dietary Supplements Tumor necrosis factor alpha Female Inflammation Mediators |
| Zdroj: | Nutrition Research. 32(11):884-892 |
| ISSN: | 0271-5317 |
| DOI: | 10.1016/j.nutres.2012.09.012 |
| Popis: | Owing to its high contents of fructooligosaccharides (FOSs), the yacon (Smallanthus sonchifolius) root is used in traditional Andean medicine as a substitute for cane sugar in diabetes and for obesity prevention. This study was designed to test the hypothesis that regular consumption of yacon works to improve the immune system. BALB/c mice were fed with the AIN-93 diet supplemented with 5% commercial FOS or either 3% or 5% yacon FOS for 30 consecutive days. Animals in the control group were fed with nonsupplemented ration. Food intake; weight gain; serum levels of IgA, IgM, and IgG; levels of fecal IgA, production of nitric oxide by peritoneal macrophages, frequencies of T and B lymphocytes in the spleen and peripheral blood, T-cell proliferation, and cytokine production were evaluated in all groups. No significant differences were observed in food intake and weight gain when the experimental and control groups were compared. Also, serum levels of IgA, IgM, and IgG; nitric oxide production in peritoneal macrophages; frequencies of T and B lymphocytes in the spleen and peripheral blood; T-cell proliferation; and production of interleukin (IL)-4, interferon-γ, IL-10, and tumor necrosis factor α did not differ in the different groups. The intake of FOS, however, led to a significant reduction of the proinflammatory cytokine IL-1β in macrophage cultures and elevation of the levels of fecal IgA. Together, these results indicate that the daily consumption of yacon does not exert negative effects on the immune system, helps to preserve an anti-inflammatory state in phagocytic cells, and improves mucosal immunity, possibly preventing the risks associated with autoimmune and metabolic diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect