Non protein bound iron as early predictive marker of neonatal brain damage
| Autor: | Mariangela Longini, Piero Vezzosi, Patrizia Paffetti, Rodolfo Bracci, Maria Gabriella Gatti, Giuseppe Buonocore, Serafina Perrone |
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| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Pediatrics Iron Brain damage Sensitivity and Specificity Statistics Nonparametric Central nervous system disease Plasma Neonatal Screening Predictive Value of Tests Neurodisability Medicine Humans Neonatology Prospective Studies Asphyxia Fetus Asphyxia Neonatorum Predictive marker business.industry Infant Newborn medicine.disease Fetal Blood Oxidative Stress Linear Models Brain Damage Chronic Neurology (clinical) medicine.symptom business Biomarkers Infant Premature |
| Zdroj: | Scopus-Elsevier |
| Popis: | Summary Of the approximately 130 million births worldwide each year, four million infants will suffer from birth asphyxia and, of these, one million will die and a similar number will develop serious sequelae. Before being able to develop effective interventions, a better understanding of the pathophysiological mechanisms leading to brain injury and an early identification of babies at high risk for brain injury are required. This study tests the predictivity of traditional and new markers of foetal oxidative stress in relation to neurodevelopmental outcome in 384 newborn infants. The results indicate plasma non protein bound iron as the best early predictive marker of neurodevelopmental outcome, with 100% sensitivity and 100% specificity for good neurodevelopmental outcome at 0‐1.16 mmol/l, and for poor neurodevelopmental outcome at values >15.2 mmol/l. The number of children with values between 1.16 and 15.2 were 195. Common use of this predictive marker in neonatology units will improve the ability of clinicians to identify those newborn babies who will develop neurodisability. |
| Databáze: | OpenAIRE |
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