Evaluation of the Antidepressant Effect of the Functional Beverage Containing Active Peptides, Menthol and Eleutherosides, and Investigation of Its Mechanism of Action in Mice
| Autor: | Huizhen Zhang, Jiajia Chen, Zhicheng Li, Zhouyu Duan, Sha Liang, Deyang Zhou, Yuanjin Qi, Xiaoni Yan |
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| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
lcsh:Biotechnology General Chemical Engineering Eleutheroside Pharmacology 01 natural sciences Industrial and Manufacturing Engineering Open field chemistry.chemical_compound monoamine behavioral testing lcsh:TP248.13-248.65 010608 biotechnology Medicine Original Scientific Papers antidepressant mechanism Active ingredient lcsh:TP368-456 business.industry functional beverage Tail suspension test lcsh:Food processing and manufacture Monoamine neurotransmitter chemistry antioxidation Antidepressant eleutheroside business Menthol Food Science Biotechnology Behavioural despair test |
| Zdroj: | Food Technology and Biotechnology, Vol 58, Iss 3, Pp 295-302 (2020) Food Technology and Biotechnology |
| ISSN: | 1334-2606 1330-9862 |
| DOI: | 10.17113/ftb.58.03.20.6568 |
| Popis: | SUMMARY Research background. Depression has become a global threat to human health. In order to solve it, researchers have conducted multi-faceted studies including diet. Many food-derived bioactive substances have shown antidepressant effects. However, there are few studies on the design of industrialized food with antidepressant effect. This study aimed to evaluate the antidepressant effect of a functional beverage made from several ingredients with potential antidepressant function and investigate its antidepressant mechanisms. Experimental approach. The beverage consists of peppermint oil, active peptides derived from bovine milk casein and Acanthopanax senticosus extract (ASE) whose active ingredient is eleutheroside. Different amounts of ASE were evaluated to determine the optimal concentration of eleutheroside in this functional beverage to deliver best antidepressant effect through extensive behavioral testing including preliminary acute stress experiments and further chronic unpredictable mild stress test. Results and conclusions. The results demonstrated that the beverage with 15.00 mg/kg of eleutheroside could significantly reduce the mice’s immobility time of tail suspension test and forced swimming test, recover mice’s sucrose preference and behavior changes in the open-field test, improve the contents of dopamine, norepinephrine, 5-hydroxytryptamine and the activity of superoxide dismutase and reduce the content of malondialdehyde in mice’s brains, which indicated that the improvement of monoamine neurotransmitter systems and antioxidation was one potential mechanism of antidepressant action. Novelty and scientific contribution. This study provides a design of antidepressant functional beverage and an efficient way for the prevention and treatment of depression. |
| Databáze: | OpenAIRE |
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