Toxicity studies of six types of carbon nanoparticles in a chicken-embryo model
| Autor: | Wanvimol Pasanphan, Gabriela Halik, André Chwalibog, Ewa Sawosz, Barbara Strojny, Marta Grodzik, Radosław W. Piast, Natalia Kurantowicz, Anna Hotowy |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
surface charge
Erythrocytes Biophysics Oxide Pharmaceutical Science Bioengineering Chick Embryo 02 engineering and technology 010501 environmental sciences medicine.disease_cause 01 natural sciences law.invention Biomaterials chemistry.chemical_compound Blood serum diamond law Toxicity Tests Drug Discovery medicine oxidative stress Animals Incubation Original Research 0105 earth and related environmental sciences graphite Chemistry Graphene graphene Organic Chemistry toxicity Oxides Organ Size General Medicine 021001 nanoscience & nanotechnology Carbon Survival Rate Liver Toxicity Drug delivery Nanoparticles Surface modification Female 0210 nano-technology Chickens Oxidative stress red blood cells Nuclear chemistry |
| Zdroj: | Kurantowicz, N, Sawosz, E, Halik, G, Strojny, B, Hotowy, A, Grodzik, M, Piast, R, Pasanphan, W & Chwalibog, A 2017, ' Toxicity studies of six types of carbon nanoparticles in a chicken-embryo model ', International Journal of Nanomedicine, vol. 2017, no. 12, 12, pp. 2887-2898 . https://doi.org/10.2147/IJN.S131960 International Journal of Nanomedicine |
| DOI: | 10.2147/IJN.S131960 |
| Popis: | In the present study, the toxicity of six different types of carbon nanoparticles (CNPs) was investigated using a chicken-embryo model. Fertilized chicken eggs were divided into the following treatment groups: placebo, diamond NPs, graphite NPs, pristine graphene, small graphene oxide, large graphene oxide, and reduced graphene oxide. Experimental solutions at a concentration of 500 μg/mL were administrated into the egg albumin. Gross pathology and the rate of survival were examined after 5, 10, 15, and 20 days of incubation. After 20 days of incubation, blood samples were collected and the weight of the body and organs measured. The relative ratio of embryo survival decreased after treatment all treatments except diamond NPs. There was no correlation between the rate of survival and the ζ-potential or the surface charge of the CNPs in solution. Body and organ weight, red blood-cell morphology, blood serum biochemical parameters, and oxidative damage in the liver did not differ among the groups. These results indicate that CNPs can remain in blood circulation without any major side effects, suggesting their potential applicability as vehicles for drug delivery or active compounds per se. However, there is a need for further investigation of their properties, which vary depending on production methods and surface functionalization. |
| Databáze: | OpenAIRE |
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