Circular RNA–MicroRNA–MRNA interaction predictions in SARS-CoV-2 infection
| Autor: | Yılmaz Mehmet Demirci, Müşerref Duygu Saçar Demirci |
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| Přispěvatelé: | AGÜ, Yaşam ve Doğa Bilimleri Fakültesi, Biyomühendislik Bölümü, Demirci, Yilmaz Mehmet, Demirci, Muserref Duygu Sacar |
| Rok vydání: | 2021 |
| Předmět: |
2019-20 coronavirus outbreak
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Computational biology Biology Article 03 medical and health sciences 0302 clinical medicine Circular RNA microRNA Humans circRNA RNA Messenger Differential expression miRNA 030304 developmental biology Regulation of gene expression 0303 health sciences Messenger RNA SARS-CoV-2 COVID-19 RNA Circular General Medicine Pathogenicity MicroRNAs machine learning 030220 oncology & carcinogenesis gene regulation TP248.13-248.65 Biotechnology |
| Zdroj: | Journal of Integrative Bioinformatics Journal of Integrative Bioinformatics, Vol 18, Iss 1, Pp 45-50 (2021) |
| ISSN: | 1613-4516 |
| DOI: | 10.1515/jib-2020-0047 |
| Popis: | This work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK, Grant No: 120E042). Different types of noncoding RNAs like microRNAs (miRNAs) and circular RNAs (circRNAs) have been shown to take part in various cellular processes including post-transcriptional gene regulation during infection. MiRNAs are expressed by more than 200 organisms ranging from viruses to higher eukaryotes. Since miRNAs seem to be involved in host-pathogen interactions, many studies attempted to identify whether human miRNAs could target severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNAs as an antiviral defence mechanism. In this work, a machine learning based miRNA analysis work flow was developed to predict differential expression patterns of human miRNAs during SARS-CoV-2 infection. In order to obtain the graphical representation of miRNA hairpins, 36 features were defined based on the secondary structures. Moreover, potential targeting interactions between human circRNAs and miRNAs as well as human miRNAs and viral mRNAs were investigated. Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) 120E042 |
| Databáze: | OpenAIRE |
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