Extracellular Vesicles Derived Human-miRNAs Modulate the Immune System in Type 1 Diabetes
Autor: | Tine Tesovnik, Jernej Kovač, Katka Pohar, Samo Hudoklin, Klemen Dovč, Nataša Bratina, Katarina Trebušak Podkrajšek, Maruša Debeljak, Peter Veranič, Emanuele Bosi, Lorenzo Piemonti, Alojz Ihan, Tadej Battelino |
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Přispěvatelé: | Tesovnik, Tine, Kovač, Jernej, Pohar, Katka, Hudoklin, Samo, Dovč, Klemen, Bratina, Nataša, Trebušak Podkrajšek, Katarina, Debeljak, Maruša, Veranič, Peter, Bosi, Emanuele, Piemonti, Lorenzo, Ihan, Alojz, Battelino, Tadej |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Chemokine type 1 diabetes medicine.medical_treatment autoimmune disease medicine.disease_cause TLR7/8 Autoimmunity Pathogenesis 03 medical and health sciences Cell and Developmental Biology 0302 clinical medicine Immune system microRNA medicine lcsh:QH301-705.5 Original Research miRNA biology Effector Cell Biology immune modulating activity 3. Good health Cell biology 030104 developmental biology Cytokine Membrane protein lcsh:Biology (General) 030220 oncology & carcinogenesis biology.protein extracellular vesicles Developmental Biology |
Zdroj: | Frontiers in Cell and Developmental Biology Frontiers in Cell and Developmental Biology, Vol 8 (2020) |
ISSN: | 2296-634X |
DOI: | 10.3389/fcell.2020.00202 |
Popis: | Extracellular vesicles with their molecular cargo can modulate target cell response and may affect the pathogenesis of diseases. The extracellular vesicles containing micro-RNAs (miRNAs), which are often studied as disease biomarkers, but rarely as mediators of the disease development. The role of extracellular vesicles derived miRNAs in type 1 diabetes is currently not well established. We observed a fraction of blood plasma extracellular vesicles positive for membrane proteins potentially associated with insulin-producing beta-cells and identified differentially expressed extracellular vesicles derived miRNAs in individuals with type 1 diabetes. These differentially expressed extracellular vesicles derived human miRNAs in participants with type 1 diabetes and participants with Langerhans islets beta-cells destruction showed the ability to activate TLR7/8 signaling cascade and increase activation as well as cytotoxicity of the effector blood immune cells with cytokine and chemokine release. Our results illustrate extracellular vesicles derived human miRNAs as modulators of the immune system in type 1 diabetes autoimmunity, providing potentially new insight into the pathogenesis of the disease, and novel molecular targets for intervention and type 1 diabetes prevention. |
Databáze: | OpenAIRE |
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