Ambulatory systolic blood pressure and obesity are independently associated with left ventricular hypertrophic remodeling in children

Autor: Christopher M. Haggerty, H. Lester Kirchner, Linyuan Jing, Christopher D. Nevius, William J. Cochran, Jonathan D. Suever, Gregory J. Wehner, Arichanah Pulenthiran, Brandon K. Fornwalt, Abba Mejia-Spiegeler, Aftab S. Chishti, Cassi M. Friday
Rok vydání: 2017
Předmět:
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
Pediatric Obesity
Blood Pressure
030204 cardiovascular system & hematology
Overweight
Severity of Illness Index
Ventricular Function
Left
Body Mass Index
0302 clinical medicine
Risk Factors
Weight loss
Prospective Studies
030212 general & internal medicine
Child
2. Zero hunger
Principal Component Analysis
Radiological and Ultrasound Technology
Age Factors
Blood Pressure Monitoring
Ambulatory
Hypertension
Cardiology
Female
Hypertrophy
Left Ventricular
Ambulatory blood pressure monitoring
medicine.symptom
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
Ambulatory blood pressure
Adolescent
Diastole
Magnetic Resonance Imaging
Cine
Concentric hypertrophy
03 medical and health sciences
Ventricular remodeling
Internal medicine
medicine
Humans
Radiology
Nuclear Medicine and imaging
Chi-Square Distribution
business.industry
Research
medicine.disease
Cross-Sectional Studies
Blood pressure
lcsh:RC666-701
Multivariate Analysis
Linear Models
Cardiovascular magnetic resonance
business
Body mass index
Zdroj: Journal of Cardiovascular Magnetic Resonance
Journal of Cardiovascular Magnetic Resonance, Vol 19, Iss 1, Pp 1-11 (2017)
ISSN: 1532-429X
Popis: Background Children with obesity have hypertrophic cardiac remodeling. Hypertension is common in pediatric obesity, and may independently contribute to hypertrophy. We hypothesized that both the degree of obesity and ambulatory blood pressure (ABP) would independently associate with measures of hypertrophic cardiac remodeling in children. Methods Children, aged 8–17 years, prospectively underwent cardiovascular magnetic resonance (CMR) and ABP monitoring. Left ventricular (LV) mass indexed to height2.7 (LVMI), myocardial thickness and end-diastolic volume were quantified from a 3D LV model reconstructed from cine balanced steady state free precession images. Categories of remodeling were determined based on cutoff values for LVMI and mass/volume. Principal component analysis was used to define a “hypertrophy score” to study the continuous relationship between concentric hypertrophy and ABP. Results Seventy-two children were recruited, and 68 of those (37 healthy weight and 31 obese/overweight) completed both CMR and ABP monitoring. Obese/overweight children had increased LVMI (27 ± 4 vs 22 ± 3 g/m2.7, p
Databáze: OpenAIRE
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