Geoffroea decorticans fruit extracts inhibit the wnt/β-catenin pathway, a therapeutic target in cancer
| Autor: | Manuel J. Aybar, Celeste Tríbulo, Nancy Vera, Gabriela C. Somaini |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Cell signaling Biophysics Xenopus Xenopus Proteins Biochemistry Xenopus laevis 03 medical and health sciences 0302 clinical medicine Transforming Growth Factor beta Neoplasms Animals Molecular Targeted Therapy Wnt Signaling Pathway Molecular Biology beta Catenin Glycoproteins biology Plant Extracts Chemistry Wnt signaling pathway Fabaceae Cell Biology biology.organism_classification Cell biology Geoffroea decorticans 030104 developmental biology Gene Expression Regulation Fruit 030220 oncology & carcinogenesis Catenin Cancer cell Intercellular Signaling Peptides and Proteins Female Signal transduction Chordin Lithium Chloride |
| Zdroj: | Biochemical and Biophysical Research Communications. 546:118-123 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2021.01.087 |
| Popis: | Geoffroea decorticans (chanar) is commonly used for culinary and medicinal purposes in rural communities. The aim of this work was to chemically characterize three Geoffroea decorticans extracts and determine their capacity to modulate the wnt/β-catenin pathway. This signaling pathway plays a key role in embryonic development but its overactivation leads to cancer cell growth. Phytochemical analysis of extracts showed presence of major classes of phytochemicals. Gas chromatography-mass spectrometry results revealed the presence of acids, esters and furanic compounds. Using Xenopus embryos as in vivo model organisms, we found that the extracts modulated dorso-ventral axis formation and rescued hyperdorsalized phenotypes produced by LiCl treatment. In agreement with these findings, Geoffroea decorticans extracts decreased β-catenin levels and suppressed the expression of wnt target genes such as xnr3 and chordin, thus demonstrating an inhibitory regulation of the wnt/β-catenin signaling pathway. All these results support a new role for Geoffroea decorticans fruit derivatives with possible anti-carcinogenic actions. |
| Databáze: | OpenAIRE |
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