Understanding the Key to Targeting the IGF Axis in Cancer: A Biomarker Assessment
| Autor: | Piyawan Tienchaiananda, Paul Haluska, Kunal A. Lodhia |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Cancer Research
Insulin Receptor Substrate Proteins Review Insulin-Like Growth Factor Receptor Bioinformatics lcsh:RC254-282 IGF system and signaling endocrine system diseases 03 medical and health sciences 0302 clinical medicine biomarker discovery Biopsy medicine insulin receptor insulin-like growth factor receptor Biomarker discovery 030304 developmental biology 0303 health sciences medicine.diagnostic_test biology IGF binding protein Cancer insulin receptor substrate proteins lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease targeted therapies 3. Good health Insulin receptor Oncology 030220 oncology & carcinogenesis Potential biomarkers biology.protein Biomarker (medicine) IGF binding proteins IGF-I receptor |
| Zdroj: | Frontiers in Oncology Frontiers in Oncology, Vol 5 (2015) |
| ISSN: | 2234-943X |
| DOI: | 10.3389/fonc.2015.00142 |
| Popis: | Type 1 insulin like growth factor receptor (IGF-1R) targeted therapies showed compelling pre-clinical evidence; however, to date, this has failed to translate into patient benefit in Phase 2/3 trials in unselected patients. This was further complicated by the toxicity, including hyperglycemia, which largely results from the overlap between IGF and insulin signaling systems and associated feedback mechanisms. This has halted the clinical development of inhibitors targeting IGF signaling, which has limited the availability of biopsy samples for correlative studies to understand biomarkers of response. Indeed, a major factor contributing to lack of clinical benefit of IGF targeting agents has been difficulty in identifying patients with tumors driven by IGF signaling due to the lack of predictive biomarkers. In this review, we will describe the IGF system, rationale for targeting IGF signaling, the potential liabilities of targeting strategies, and potential biomarkers that may improve success. |
| Databáze: | OpenAIRE |
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