Clinicopathological significance of overexpression of TSPAN1, Ki67 and CD34 in gastric carcinoma
| Autor: | Jianwei Zhu, Guei-lan Wang, Li Chen, Yu Wang, Xin-Yu Li, York-Yuan Zhu |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
0301 basic medicine
Adult Male Cancer Research Pathology medicine.medical_specialty Tetraspanins CD34 Antigens CD34 Gastric carcinoma Disease Kaplan-Meier Estimate 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms Carcinoma medicine Biomarkers Tumor Humans Lymph node Aged Neoplasm Staging business.industry Membrane Proteins General Medicine Middle Aged medicine.disease Immunohistochemistry Up-Regulation Gene Expression Regulation Neoplastic 030104 developmental biology medicine.anatomical_structure Ki-67 Antigen Oncology 030220 oncology & carcinogenesis Female business Infiltration (medical) |
| Zdroj: | Tumori. 94(4) |
| ISSN: | 0300-8916 |
| Popis: | To investigate the expression of TSPAN1 (Gene ID: 10103), Ki67 and CD34 in gastric carcinomas and the clinicopathological significance, the expression of TSPAN1, Ki67 and CD34 was detected in 86 cases of gastric carcinoma, paraffin-embedded sections using an immunohistochemical method. The rates of overexpression of TSPAN1, Ki67 and CD34 in gastric carcinomas were 56.98%, 74.42%, and 62.79%, respectively. The overexpression of these markers was positively correlated with clinical stage and negatively correlated with survival rates (at 3 and 5 years). The overexpression of TSPAN1 and Ki67 was negatively correlated with carcinoma differentiation, and the overexpression of TSPAN1 and CD34 was positively correlated with infiltration and lymph node status of the tumor. Thus, overexpression of TSPAN1, Ki67 and CD34 in gastric cancer tissues is associated with development of the cancer. The detection of expression of TSPAN1, Ki67 and CD34 in gastric cancer may provide useful prognostic information for patients with the disease. |
| Databáze: | OpenAIRE |
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