Quantitative autoradiographic mapping of a novel serotonin receptor-5-HT1S
| Autor: | F P Zemlan, R M Murphy |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
8-Hydroxy-2-(di-n-propylamino)tetralin Quantitative Autoradiography Chemistry General Neuroscience Central nervous system Somatosensory system Spinal cord Ligands Rats Rats Sprague-Dawley Nociception medicine.anatomical_structure Spinal Cord Receptors Serotonin medicine Biophysics Animals Autoradiography Binding site Receptor Neuroscience 5-HT receptor Synaptosomes |
| Zdroj: | Neuroreport. 3(10) |
| ISSN: | 0959-4965 |
| Popis: | The spinal cord distribution of a recently identified, high affinity 3H-5-HT binding site, the 5-HT1S receptor was studied employing quantitative autoradiography with microdensitometry. The laminar distribution and density of other high affinity 3H-5-HT binding sites present in rat spinal cord, 5-HT1A, 5-HT1B and 5-HT1C, was also determined. The greatest density of 5-HT1S receptors was found in the superficial dorsal horn laminae, the autonomic nuclei around the central canal and the ventral motor nuclei. Smaller, variable densities of 5-HT1S receptors were observed in other spinal cord regions. A similar spatial pattern of receptor density was observed for 5-HT1A, 5-HT1B and 5-HT1C receptors. The distribution of 5-HT1S receptors suggests functional modulation of somatosensory input to spinal cord as well as control of visceral and somatomotor activity. |
| Databáze: | OpenAIRE |
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