Prevalence of Focal Inner, Middle, and Combined Retinal Thinning in Diabetic Patients and Its Relationship With Systemic and Ocular Parameters
| Autor: | David Sarraf, Leonardo Provetti Cunha, Leandro Cabral Zacharias, Adrian Au, Helen Nazareth Veloso dos Santos, Maria Fernanda Abalem, Rony Carlos Preti, Rafael Garcia, Srinivas R. Sadda, Gustavo Sakuno, Claudio Iovino, Mário Luiz Ribeiro Monteiro |
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| Přispěvatelé: | Preti, R. C., Iovino, C., Abalem, M. F., Garcia, R., Dos Santos, H. N. V., Sakuno, G., Au, A., Cunha, L. P., Zacharias, L. C., Monteiro, M. L. R., Sadda, S. R., Sarraf, D. |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Systemic disease Visual acuity genetic structures Biomedical Engineering Article Macular Edema Coronary artery disease 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ophthalmology Diabetes mellitus Diabetes Mellitus Prevalence Medicine Humans Retinal thinning Macular edema Cross-Sectional Studie optical coherence tomography Diabetic Retinopathy business.industry Diabetes Mellitu Retinal Diabetic retinopathy medicine.disease eye diseases deep capillary plexus ischemia 030104 developmental biology Cross-Sectional Studies chemistry 030221 ophthalmology & optometry sense organs retinal thinning medicine.symptom business superficial capillary plexus ischemia Tomography Optical Coherence Human |
| Zdroj: | Translational Vision Science & Technology |
| ISSN: | 2164-2591 |
| Popis: | Purpose To determine the prevalence of focal inner, middle, and combined inner/middle retinal thinning (FIRT, FMRT, and FCRT, respectively) in different stages of diabetic retinopathy (DR) without diabetic macular edema and to assess the relationship between such findings with ocular and systemic parameters. Methods This was a cross-sectional, comparative study comprising healthy participants and diabetic patients with different stages of DR. Forty-nine horizontal macular B-scans from the selected eye were obtained using spectral-domain optical coherence tomography (SD-OCT) and analyzed for the presence of FIRT, FMRT, or FCRT and any relationship with systemic and ocular parameters. Focal retinal thinning (FRT) was subjectively defined as any evidence of inner and/or middle retinal thinning. Results A total of 190 participants (52 healthy participants and 138 diabetic patients) were included. A higher prevalence of FRT was observed in eyes with advanced DR versus healthy eyes and versus diabetic eyes with no DR or mild DR. FIRT and FCRT were significantly greater in eyes with proliferative DR treated with pan-retinal photocoagulation, and FMRT was significantly more common in eyes with severe nonproliferative DR. FRT was significantly more common in patients with coronary artery disease and was positively correlated with diabetes duration, serum creatinine, and glycosylated hemoglobin and negatively correlated with age, estimated glomerular filtration rate, and visual acuity. Conclusions FRT occurs in all stages of DR and is increasingly prevalent with increasing severity of DR. Translational relevance OCT identification of FRT may provide a surrogate biomarker of retinal and systemic disease in diabetic patients. |
| Databáze: | OpenAIRE |
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