FAM83H-AS1 is upregulated and predicts poor prognosis in colon cancer
| Autor: | Lei Yang, Yakun Wang, Jinpeng Cui, Jinjing Tan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Poor prognosis Colorectal cancer Smad Proteins RM1-950 Kaplan-Meier Estimate 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Expression pattern medicine Humans Clinical significance Proportional Hazards Models Pharmacology business.industry Cancer General Medicine Middle Aged medicine.disease HCT116 Cells Prognosis FAM83H-AS1 digestive system diseases Long non-coding RNA Colon cancer Up-Regulation Gene Expression Regulation Neoplastic 030104 developmental biology 030220 oncology & carcinogenesis Gene Knockdown Techniques Colonic Neoplasms Multivariate Analysis Cancer research Female RNA Long Noncoding Therapeutics. Pharmacology business Long noncoding RNA |
| Zdroj: | Biomedicine & Pharmacotherapy, Vol 118, Iss, Pp-(2019) |
| ISSN: | 1950-6007 |
| Popis: | Long noncoding RNAs (LncRNAs) have been proven to participate in many principal pathways during colonic mucosa tumourigenesis. FAM83H-AS1 has been identified as one of the LncRNAs that is dysregulated in multi-type cancers. Here, our purpose was to determine the expression pattern and clinical significance of FAM83H-AS1 and further analyse its prognostic value in colon cancer. FAM83H-AS1 expression was examined in 90 patients with colon cancer by RNAscope in situhybridization, and the expression levels were analysed with the overall survival (OS) rates for patients with colon cancer. TCGA datasets derived from colon cancer (COAD) were used to further validate the main findings. We demonstrated that the expression of FAM83H-AS1 was significantly higher in cancer tissues than in paired normal mucosa from colon cancer patients (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect