Early versus late misoprostol administration after mifepristone for medical abortion
| Autor: | Irina Masri, Rene Tendler, Marwan Odeh, Mohamad Kais, Jacob Bornstein |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Gestational Age Drug Administration Schedule Pregnancy Outcome Assessment Health Care medicine Humans Prospective Studies Misoprostol Fetal Movement Abortifacient Agents Nonsteroidal business.industry Obstetrics Abortifacient Agents Steroidal Uterus Obstetrics and Gynecology Abortion Induced General Medicine Mifepristone medicine.disease Medical abortion Regimen Female business Administration (government) medicine.drug |
| Zdroj: | Archives of gynecology and obstetrics. 292(5) |
| ISSN: | 1432-0711 |
| Popis: | To evaluate the successful medical termination of pregnancy comparing two regimens: misoprostol 2 or 48 h after mifepristone administration.Prospective randomized study.Department of Obstetrics and Gynecology.One hundred pregnant women admitted for medical termination of pregnancy were enrolled; no pregnancies were over 55 days gestational age.All subjects were randomly assigned for misoprostol administration either 2 or 48 h after mifepristone. All participants underwent transvaginal ultrasound examination for uterine contents 48 h and 3 weeks after mifepristone.Procedure failure, defined as the presence of fetal heart activity, presence of a gestational sac, or a need for uterine curettage after misoprostol administration.Each group consisted of 50 women. Fetal heart activity was significantly more frequent after 48 h in the 2-h interval group (10/50) than in the 48-h interval group (0/50) (p = 0.002). Three weeks after misoprostol administration, fetal heart activity was present in 4/50 (8 %) in the 2-h interval group (p = 0.118) and none of the 48-h interval group. At 48 h residual tissue was present in 13/50 (26 %) and 5/50 (10 %) in the 2 and 48-h interval groups, respectively (p = 0.031); this was reduced to 12/50 (24 %) compared to 5/50 (10 %) in the two groups, respectively (p = 0.054) after 3 weeks.Successful medical termination of pregnancy can be achieved using misoprostol administration 2 h after mifepristone in 76 % of cases. However, this regimen is not recommended as it is significantly inferior to the traditional 48-h interval regimen. |
| Databáze: | OpenAIRE |
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