Flagellar Propulsion of Sperm Cells Against a Time-Periodic Interaction Force

Autor: Zihan Wang, Anke Klingner, Veronika Magdanz, Merijn W. Hoppenreijs, Sarthak Misra, Islam S. M. Khalil
Přispěvatelé: Surgical Robotics, MESA+ Institute, TechMed Centre, Biomechanical Engineering, Man, Biomaterials and Microbes (MBM), ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), ​Robotics and image-guided minimally-invasive surgery (ROBOTICS)
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Advanced Biology, 7(1):2200210. Wiley
Advanced Biology, 7(1):2200210. WILEY-V C H VERLAG GMBH
ISSN: 2701-0198
Popis: Sperm cells undergo complex interactions with external environments, such as a solid-boundary, fluid flow, as well as other cells before arriving at the fertilization site. The interaction with the oviductal epithelium, as a site of sperm storage, is one type of cell-to-cell interaction that serves as a selection mechanism. Abnormal sperm cells with poor swimming performance, the major cause of male infertility, are filtered out by this selection mechanism. In this study, collinear bundles, consisting of two sperm cells, generate propulsive thrusts along opposite directions and allow to observe the influence of cell-to-cell interaction on flagellar wave-patterns. The developed elasto-hydrodynamic model demonstrates that steric and adhesive forces lead to highly symmetrical wave-pattern and reduce the bending amplitude of the propagating wave. It is measured that the free cells exhibit a mean flagellar curvature of 6.4 +/- 3.5 rad mm(-1) and a bending amplitude of 13.8 +/- 2.8 rad mm(-1). After forming the collinear bundle, the mean flagellar curvature and bending amplitude are decreased to 1.8 +/- 1.1 and 9.6 +/- 1.4 rad mm(-1), respectively. This study presents consistent theoretical and experimental results important for understanding the adaptive behavior of sperm cells to the external time-periodic force encountered during sperm-egg interaction.
Databáze: OpenAIRE
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