Triggered activity in the heart: cellular mechanisms of early after-depolarizations
| Autor: | J. C. Makielski, C. T. January, V. Chau |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
business.industry Ischemia Action Potentials Arrhythmias Cardiac Coronary Disease medicine.disease Ion Channels Reperfusion therapy Heart Conduction System Internal medicine medicine Cardiology Humans Calcium Channels Cardiology and Cardiovascular Medicine business Ion channel |
| Zdroj: | European Heart Journal. 12:4-9 |
| ISSN: | 1522-9645 0195-668X |
| Popis: | The arrhythmogenic effects of ischaemia and reperfusion result from the complex interplay of normal ion channels reacting to the ischaemic environment, channels made abnormal by ischaemic modification, the appearance of new currents normally not present, and possible ischaemic alteration of metabolic electrogenic processes. In this report the cellular mechanisms thought to underlie the different types of triggered activity will be discussed. The role of Ca2+ channels and Ca2+ 'window' current in the generation of early after-depolarizations (EADs) will be elucidated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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