Alterations in brain metabolism during the first year of HIV infection
| Autor: | Caroline Soulas, R. G. Gonzalez, Margaret R. Lentz, Elkan F. Halpern, Eric S. Rosenberg, Vallent Lee, Hyun Wha Kim, Woong-Ki Kim, Kenneth C. Williams, Nagagopal Venna |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty Magnetic Resonance Spectroscopy Neurology Cost effectiveness Lipopolysaccharide Receptors HIV Infections CD16 Biology GPI-Linked Proteins Basal Ganglia Monocytes Article Choline White matter Cellular and Molecular Neuroscience chemistry.chemical_compound Western blot Virology medicine Humans Dementia Longitudinal Studies Aspartic Acid medicine.diagnostic_test Monocyte Receptors IgG HIV virus diseases Middle Aged Viral Load Lipid Metabolism medicine.disease Frontal Lobe medicine.anatomical_structure Anti-Retroviral Agents chemistry Immunology RNA Viral Neurology (clinical) Inositol |
| Zdroj: | Journal of NeuroVirology. 17:220-229 |
| ISSN: | 1538-2443 1355-0284 |
| Popis: | Migration of both uninfected and infected monocytes into the brain during acute HIV infection likely initiates metabolic changes that can be observed with magnetic resonance spectroscopy (MRS). Herein, we measured changes in brain metabolism during the first year of HIV infection and examined the relationship of these metabolite levels to CD16+ monocyte populations measured in the blood. MRS was performed on nine HIV+ subjects identified during acute HIV infection and nine seronegative control subjects. HIV+ subjects were examined within 90 days of an indeterminate Western blot, then again 2 and 6 months later, during early infection. Blood samples were collected for plasma viral RNA and monocyte subset quantification. HIV+ subjects were identified with acute viral ailment and did not display severe cognitive deficits such as dementia or minor cognitive motor disorder. Changes in lipid membrane metabolism (choline levels) in the frontal cortex and white matter were observed during the initial year of HIV infection. Greater numbers of CD16+ monocytes were associated with lower N-acetylaspartate levels and higher choline levels in the brain. These results suggest that HIV infection induces metabolic changes in the brain early during infection and that these changes may be related to monocyte dynamics in the periphery. |
| Databáze: | OpenAIRE |
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