Gender-Attributable Differences in Outcome of Ankylosing Spondylitis: Long-Term Results from the Outcome in Ankylosing Spondylitis International Study
| Autor: | Sofia Ramiro, Désirée van der Heijde, Ivette Essers, Maxime Dougados, Astrid van Tubergen, Casper Webers, Carmen Stolwijk, Robert Landewé, Filip Van den Bosch |
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| Přispěvatelé: | Promovendi PHPC, Interne Geneeskunde, RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation, MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), MUMC+: MA Reumatologie (9) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Internationality Time Factors Anti-Inflammatory Agents DISEASE-ACTIVITY Severity of Illness Index Disability Evaluation HEALTH SURVEY SF-36 Quality of life QUALITY-OF-LIFE gender longitudinal studies Medicine Pharmacology (medical) Prospective cohort study BASDAI INDEX Pain Measurement Middle Aged Ankylosing Spondylitis Quality of Life Exercise Therapy Treatment Outcome Cohort Disease Progression Female epidemiology AXIAL SPONDYLOARTHRITIS SYNDESMOPHYTES Adult medicine.medical_specialty Risk Assessment RADIOGRAPHIC PROGRESSION BATH Sex Factors Rheumatology ankylosing spondylitis Severity of illness Humans sex Spondylitis Ankylosing COHORT Analysis of Variance Ankylosing spondylitis business.industry medicine.disease SPONDYLARTHRITIS Radiography Cross-Sectional Studies Multivariate Analysis Quality of Life Physical therapy business BASFI Follow-Up Studies |
| Zdroj: | Arthritis and Rheumatology, 66, S1137-S1137 Rheumatology, 55(3), 419-428. Oxford University Press |
| ISSN: | 1462-0324 |
| Popis: | Objectives. To investigate gender-attributable differences regarding clinical outcome [disease activity, physical function and quality of life (QoL)] and radiographic damage in patients with AS over time.Methods. Data from the Outcome in AS International Study were used. Disease activity was assessed by the BASDAI, ASDAS and CRP; physical function by BASFI; QoL by the Short Form-36, Ankylosing Spondylitis Quality of Life (ASQoL) score and European Quality Of Life scale; and radiographic damage by the modified Stoke AS Spine Score (mSASSS). Cross-sectional comparative analyses were done at baseline. Next, separate models were created to assess gender-attributable differences on each outcome measure over time using time-adjusted generalized estimating equations.Results. A total of 216 patients [154 (72.3%) males, mean age 43.6 years (S.D. 12.7), symptom duration 20.5 years (s.o. 11.8), mean follow-up duration 8.3 years (S.D. 4.1)] were included. At baseline, male compared with female patients had lower self-reported disease activity (BASDAI 3.2 vs 3.9, P=0.03) but more radiographic damage (mSASSS 13.8 vs 6.5, P=0.02). No significant gender-attributable differences in other clinical parameters were found. In multivariable analysis, male gender was significantly associated with a better ASQoL (B = -1.18, 95% CI: -2.17, -0.20, P=0.02), and in a separate model with a higher mSASSS over time (B = 8.24, 95% CI: 4.38, 12.09, P Conclusion. In this prospective cohort study, no gender-attributable differences in disease activity or physical function over time were found. However, radiographic damage was more severe in males. Furthermore, males had a better QoL over time. |
| Databáze: | OpenAIRE |
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