Randomized controlled trial of remote ischemic preconditioning and atrial fibrillation in patients undergoing cardiac surgery
| Autor: | Amir Lotfi, Ananth Kashikar, Miguel Giannoni, Auras R. Atreya, Senthil K. Sivalingam, Paul Visintainer, Daniel T. Engelman, Hossein Eftekhari |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
macromolecular substances 030204 cardiovascular system & hematology Post-operative atrial fibrillation Coronary artery disease Chronic ischemic heart disease law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine medicine In patient 030212 general & internal medicine business.industry Atrial fibrillation Other treatment Cardiac surgery medicine.disease Remote ischemic preconditioning Anesthesia Randomized Controlled Trial cardiovascular system Cardiology Ischemic preconditioning Cardiology and Cardiovascular Medicine business |
| Zdroj: | World Journal of Cardiology |
| ISSN: | 1949-8462 |
| Popis: | AIM To study whether remote ischemic preconditioning (RIPC) has an impact on clinical outcomes, such as post-operative atrial fibrillation (POAF). METHODS This was a prospective, single-center, single-blinded, randomized controlled study. One hundred and two patients were randomized to receive RIPC (3 cycles of 5 min ischemia and 5 min reperfusion in the upper arm after induction of anesthesia) or no RIPC (control). Primary outcome was POAF lasting for five minutes or longer during the first seven days after surgery. Secondary outcomes included length of hospital stay, incidence of inpatient mortality, myocardial infarction, and stroke. RESULTS POAF occurred at a rate of 54% in the RIPC group and 41.2% in the control group (P = 0.23). No statistically significant differences were noted in secondary outcomes between the two groups. CONCLUSION This is the first study in the United States to suggest that RIPC does not reduce POAF in patients with elective or urgent cardiac surgery. There were no differences in adverse effects in either group. Further studies are required to assess the relationship between RIPC and POAF. |
| Databáze: | OpenAIRE |
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