Synthesis and antiproliferative activity of new 1,5-disubstituted tetrazoles bearing hydrazone moiety

Autor:	Şafak Ulusoylar Yıldırım, Gülhan Turan-Zitouni, Zafer Asım Kaplancıklı, Usama Abu Mohsen, Ahmet Özdemir, Gülşen Akalın Çiftçi, Leyla Yurttaş
Přispěvatelé:	Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Kaplancıklı, Zafer Asım, Yurttaş, Leyla, Özdemir, Ahmet, Turan, Gülhan, Çiftçi, Gülsen Akalın
Jazyk:	angličtina
Rok vydání:	2014
Předmět:	chemistry.chemical_classification DNA synthesis Stereochemistry Organic Chemistry Hydrazone Thio Carbon-13 NMR Antiproliferative Activity chemistry.chemical_compound chemistry Caspase-3 Mtt Assay Proton NMR Moiety MTT assay Tetrazole General Pharmacology Toxicology and Pharmaceutics
Popis:	WOS: 000330766600050 A new class of tetrazole-hydrazone derivatives including chloro-substituted phenyl moiety were synthesized to perform anticancer activity screening. The structural elucidation of the compounds was performed by IR, H-1 NMR, C-13 NMR, MS spectral, and elemental analyses data. Anticancer effect of the compounds was evaluated against A549 and C6 tumor cell lines. MTT, analysis of DNA synthesis and analysis of caspase-3 activation assays were carried out for anticancer activity investigations. Compounds N'-(2-chlorobenzylidene)-4-[(1-phenyl-1H-tetrazole-5-yl)thio]butanohydrazide (3d), N'-(2,3-dichlorobenzylidene)-4-[(1-phenyl-1H-tetrazole-5-yl)thio]butanohydrazide (3d), and N'-(3,4-dichlorobenzylidene)-4-[(1-phenyl-1H-tetrazole-5-yl)thio]butanohydrazide (3e) showed significant anticancer activity. Anticancer screening tests also indicated that compound 3d has potential on C6 tumor cells with apoptotic pathway.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe63ca9a69f99670542f005ce94095e9 https://hdl.handle.net/11421/13538 Zobrazit plný text záznamu