Antidepressant-like effect of onion (Allium cepa L.) powder in a rat behavioral model of depression
| Autor: | Yoshichika Kawai, Hiroyuki Sakakibara, Saki Yoshino, Junji Terao |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Dopamine Hypothalamus Applied Microbiology and Biotechnology Biochemistry Analytical Chemistry chemistry.chemical_compound Internal medicine Onions medicine Animals Neurotransmitter Molecular Biology Neurotransmitter Agents biology Behavior Animal Liliaceae Depression Plant Extracts fungi Organic Chemistry Dopaminergic food and beverages General Medicine biology.organism_classification Antidepressive Agents Rats Disease Models Animal Endocrinology medicine.anatomical_structure chemistry Allium Antidepressant Corticosterone human activities Hypothalamic–pituitary–adrenal axis Biotechnology Behavioural despair test |
| Zdroj: | Bioscience, biotechnology, and biochemistry. 72(1) |
| ISSN: | 1347-6947 |
| Popis: | The present study evaluated the antidepressant-like effect of the quercetin-rich vegetable, onion, by using the rat behavioral model of depression, the forced swimming test (FST). Daily administration of onion powder at a dosage of 50 mg/kg of body weight/day for 14 days significantly reduced the immobility time in FST without changing the motor dysfunction, indicating that the daily consumption of onion exerted antidepressant-like activity. The plasma corticosterone level was elevated after an FST trial, and pretreatment with onion powder did not modulate this elevation. Although the FST trial tended to increase the dopaminergic activity in the rat hypothalamus, the administration of onion powder (50 mg/kg) suppressed the increase in the turnover of this neurotransmitter. However, the same prevention was also observed with a higher dosage of onion, in which no significant antidepressant effect was apparent. The results of the present study suggest that onion exerted antidepressant-like activity in a behavioral model that acted independently of the hypothalamic-pituitary-adrenal axis. |
| Databáze: | OpenAIRE |
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