Clinical characteristics of 17 adult patients with epidemic myalgia associated with human parechovirus type 3 infection
Autor: | Hikaru Nagasawa, Takahiro Yamada, Katsumi Mizuta, Emiko Suzuki, Katsurou Kurokawa, Manabu Wada, Tatsushi Yamakawa |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
myalgia Adult Male Reflex Stretch medicine.medical_specialty Time Factors Fever 030106 microbiology Neural Conduction Parechovirus Pleurodynia Epidemic Gastroenterology F wave Disease Outbreaks 03 medical and health sciences Young Adult 0302 clinical medicine Japan Internal medicine medicine Humans 030212 general & internal medicine Muscle Skeletal Myositis Muscle Weakness Picornaviridae Infections business.industry Human parechovirus Muscle weakness Infant Middle Aged medicine.disease Trunk Median nerve Immunology Female Neurology (clinical) Seasons medicine.symptom business Scrotal Pain Magnetic Resonance Angiography |
Zdroj: | Rinsho shinkeigaku = Clinical neurology. 57(9) |
ISSN: | 1882-0654 |
Popis: | We investigated 17 adult cases (14 males and 3 females) of myalgia induced by human parechovirus type 3 (HPeV3) infection, treated during the summers of 2008, 2011, 2014, and 2016. The patients were aged between 21 and 50 years. The limbs and trunk of all patients were affected, and severe myalgia, muscle weakness, and decreased grip strength were observed. In addition to myalgia and muscle weakness, symptoms included fever in 14 (82%), upper respiratory inflammation in 8 (47%), gastroenteritis in 4 (24%), and scrotal pain in 4 (29% of males) patients. Tendon reflexes were preserved, and serum creatine kinase level increased in all but 1 patient. Spinal MRI was performed for 3 patients, with normal results. Musculoskeletal MRI scans showed abnormal signals in the femoral muscles in 2 of 5 patients. In a nerve conduction test, the frequency of F wave appearance in the median nerve was 40% or less in 5 of 9 patients, and repeater F waves were seen in 2 patients. Of these, 7 patients had infants in their families, and developed fever around the same time; they may have been infected by these infants. All patients recovered within 1-2 weeks. HPeV3 infection is characterized by severe myalgia, and is frequently observed in summer every 2-3 years. |
Databáze: | OpenAIRE |
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