Prevalence of hepatitis B or C virus infections in patients with non‐Hodgkin's lymphoma
| Autor: | Hidehiro Nishi, Hajime Nawata, Hiroaki Iwamoto, Masaki Yokota, Masami Kuniyoshi, Shuichi Inaba, Munechika Enjoji, Naoko Kinukawa, Yoshiaki Maeda, Hironori Sakai, Marie Fukutomi, Koichiro Muta, Naokuni Uike, Kazuhiro Kotoh, Junji Nishimura, Makoto Nakamuta |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Hepatitis B virus medicine.medical_specialty Working Formulation Hepatitis C virus Population Hepacivirus medicine.disease_cause Gastroenterology Japan immune system diseases hemic and lymphatic diseases Internal medicine Prevalence medicine Humans education Aged education.field_of_study Hepatology business.industry Lymphoma Non-Hodgkin virus diseases Middle Aged Hepatitis B medicine.disease Hepatitis C digestive system diseases Non-Hodgkin's lymphoma Immunology Population study Female Viral disease business |
| Zdroj: | Journal of Gastroenterology and Hepatology. 16:215-219 |
| ISSN: | 1440-1746 0815-9319 |
| DOI: | 10.1046/j.1440-1746.2001.02406.x |
| Popis: | Background: Hepatitis C virus (HCV) and hepatitis B virus (HBV) are not only hepatotropic, but also lymphotropic viruses. Recently, some reports suggested that these viruses may participate in the development of malignant lymphoproliferative disorders. Methods: We investigated the prevalence of HCV or HBV infection in 348 patients with non-Hodgkin's lymphoma (NHL). We also compared these prevalences with those in blood donors as a control group representing the general population in our area (n = 1 513 358). Next, we evaluated the clinical and pathologic characteristics of HCV- or HBV-infected NHL cases. Non-Hodgkin's lymphoma was classified according to the Working Formulation classification. Results: Thirty-seven cases (14.9%) were found to be infected with HCV or HBV; of these, 20 (8.1%) were infected with HCV, and 17 (6.9%) with HBV. In male NHL patients, the rate of HCV infection was significantly higher than in an age- and sex-matched population in the same area (P < 0.001, Mantel– Haenszel test). The rate of HBV infection also tended to be higher in the population (P = 0.0551). In contrast, in female NHL patients, the rate of HCV or HBV infection was not higher than in the general population. In HCV-infected cases, 15 cases (75%) had B-cell NHL and 16 cases (80%) were classified as being in the intermediate grade; B-cell NHL comprised 83% of all NHL cases. In HBV-infected NHL cases, 11 (65%) were of B-cell type and 10 (58%) were classified as being in the intermediate grade. Conclusions: The high prevalence of HCV or HBV infections in our study population provides epidemiologic evidence suggesting that HCV and HBV infections may be involved in the development of a subgroup of NHL in males. Our investigation also revealed that both HCV- and HBV-infected NHL patients showed certain similarities in clinical and pathologic manifestations. |
| Databáze: | OpenAIRE |
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