The 4G/4G PAI-1 genotype is associated with elevated plasma PAI-1 levels regardless of variables of the metabolic syndrome and smoking status. A population-based study in Spanish population
| Autor: | C. Fernández-Pérez, Carina Zabena, José L. González-Sánchez, M. T. Martínez-Larrad, M. J. Martínez-Calatrava, M. Serrano-Ríos |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Waist Genotype Endocrinology Diabetes and Metabolism Population Physiology Endocrinology Polymorphism (computer science) Internal medicine Linear regression Epidemiology Plasminogen Activator Inhibitor 1 Internal Medicine medicine Humans education Aged Metabolic Syndrome education.field_of_study business.industry Leptin Smoking Middle Aged medicine.disease Cross-Sectional Studies Female Metabolic syndrome business |
| Zdroj: | Diabetes, obesitymetabolism. 9(1) |
| ISSN: | 1462-8902 |
| Popis: | Reported data about the effect of the 4G/5G PAI-1 polymorphism on plasma PAI-1 levels are controversial. This study was designed to determine the relative effect of the 4G/5G PAI-1 polymorphism on high plasma PAI-1 levels after adjustment for metabolic syndrome - related variables, and to test if this effect is modified by the smoking status. Six hundred and thirty one unrelated subjects (292 men; 35-74 years), from a cross-sectional population-based epidemiological survey in the province of Segovia (Spain) were studied. The higher frequency of high PAI-1 levels was found in 4G/4G subjects (5G/5G 19.4%, 4G/5G 21.6%, 4G/4G 33.7%, p = 0.003). A multiple regression model, adjusted for gender, age, BMI, waist circumference, triglycerides, HDL-cholesterol, HOMA IR and leptin, showed this adjOR: 4G/4G vs 5G/5G: 2.22, p = 0.008. When smoking status - 4G/5G PAI-1 interaction was included as an independent variable these results were not modified. Our results indicate that the 4G/4G PAI-1 genotype might be strongly associated with high PAI-1 levels regardless of metabolic syndrome-related variables and smoking status. |
| Databáze: | OpenAIRE |
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